Results 71 to 80 of about 36,775 (295)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

MEGA-RAG: a retrieval-augmented generation framework with multi-evidence guided answer refinement for mitigating hallucinations of LLMs in public health

Frontiers in Public Health
IntroductionThe increasing adoption of large language models (LLMs) in public health has raised significant concerns about hallucinations-factually inaccurate or misleading outputs that can compromise clinical communication and policy decisions.MethodsWe
Shan Xu, Shan Xu, Zhaokun Yan, Chengxiao Dai, Chengxiao Dai, Fan Wu   +5 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Using Retrieval vs. Cache Augmented Generation for a Pok´emon Chatbot

Proceedings of the International Florida Artificial Intelligence Research Society Conference
Cache Augmented Generation (CAG) can be an alternative to Retrieval Augmented Generation (RAG). There are differences between the two frameworks, but they work largely in the same way.
Cengiz Gunay, Jonathan Tran
doaj   +1 more source

Question Decomposition for Retrieval-Augmented Generation

Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 4: Student Research Workshop)
Grounding large language models (LLMs) in verifiable external sources is a well-established strategy for generating reliable answers. Retrieval-augmented generation (RAG) is one such approach, particularly effective for tasks like question answering: it retrieves passages that are semantically related to the question and then conditions the model on ...
Paul J. L. Ammann, Jonas Golde, Alan Akbik   +2 more
openaire   +2 more sources

Rethinking Relevance: How Noise and Distractors Impact Retrieval-Augmented Generation [PDF]

Retrieval-Augmented Generation (RAG) systems enhance the performance of Large Language Models (LLMs) by incorporating external information fetched from a retriever component.
Campagnano, Cesare, Tonellotto, Nicola, Silvestri, Fabrizio, Siciliano, Federico, Trappolini, Giovanni, Filice, Simone, Maarek, Yoelle, Cuconasu, Florin   +7 more
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Retrieval-Augmented Generation with Graphs (GraphRAG)

CoRR
Retrieval-augmented generation (RAG) is a powerful technique that enhances downstream task execution by retrieving additional information, such as knowledge, skills, and tools from external sources. Graph, by its intrinsic "nodes connected by edges" nature, encodes massive heterogeneous and relational information, making it a golden resource for RAG in
Haoyu Han 0001, Yu Wang 0160, Harry Shomer, Kai Guo 0003, Jiayuan Ding, Yongjia Lei, Mahantesh Halappanavar, Ryan A. Rossi, Subhabrata Mukherjee, Xianfeng Tang, Qi He 0002, Zhigang Hua, Bo Long, Tong Zhao 0003, Neil Shah, Amin Javari, Yinglong Xia, Jiliang Tang   +17 more
openaire   +2 more sources

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source