Results 71 to 80 of about 1,650,736 (328)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
WIKI STREAMS: Wikipedia Article Recent Edit Retrieval System using Hierarchical Stream Clustering [PDF]
, 2021 Arun Manicka Raja M +1 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Transfer Learning for Named Entity Recognition in Financial and Biomedical Documents
Information, 2019 Recent deep learning approaches have shown promising results for named entity recognition (NER). A reasonable assumption for training robust deep learning models is that a sufficient amount of high-quality annotated training data is available.
Sumam Francis +2 more
doaj +1 more source
Peer to Peer Information Retrieval: An Overview [PDF]
, 2012 Peer-to-peer technology is widely used for file sharing. In the past decade a number of prototype peer-to-peer information retrieval systems have been developed. Unfortunately, none of these have seen widespread real- world adoption and thus, in contrast
Hiemstra, Djoerd +2 more
core +3 more sources
Phase retrieval and norm retrieval
, 2014 Phase retrieval has become a very active area of research. We will classify when phase retrieval by Parseval frames passes to the Naimark complement and when phase retrieval by projections passes to the orthogonal complements. We introduce a new concept we call norm retrieval and show that this is what is necessary for passing phase retrieval to ...
Bahmanpour, Saeid +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Routine Inferior Vena Cava Filter Retrieval: A Cost Minimization Analysis of Loop Snare Versus Rigid Endobronchial Forceps Assisted Retrieval Techniques [PDF]
, 2022 John F. Swietlik +3 more
openalex +1 more source