Results 71 to 80 of about 863,584 (308)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Exploring structured documents and query formulation techniques for patent retrieval [PDF]
, 2009 This paper presents the experiments and results of DCU in CLEF-IP 2009. Our work applied standard information retrieval (IR) techniques to patent search. Different experiments tested various methods for the patent retrieval, including query formulation,
Magdy, Walid +9 more
core +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Priors for Diversity and Novelty on Neural Recommender Systems
Proceedings, 2019 PRIN is a neural based recommendation method that allows the incorporation of item prior information into the recommendation process. In this work we study how the system behaves in terms of novelty and diversity under different configurations of item ...
Alfonso Landin +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Building High-Quality Datasets for Information Retrieval Evaluation at a Reduced Cost
Proceedings, 2019 Information Retrieval is not any more exclusively about document ranking. Continuously new tasks are proposed on this and sibling fields. With this proliferation of tasks, it becomes crucial to have a cheap way of constructing test collections to ...
David Otero +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Journal of Big DataGenerative models play a pivotal role in speech and audio generation, and recent advancements have expanded their applications in medical diagnosis. This study provides a comprehensive comparative analysis of various generative models, focusing on their ...
Esraa Hassan, Nora El-Rashidy
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Investigating cross-language speech retrieval for a spontaneous conversational speech collection [PDF]
, 2006 Cross-language retrieval of spontaneous speech combines the challenges of working with noisy automated transcription and language translation. The CLEF 2005 Cross-Language Speech Retrieval (CL-SR) task provides a standard test collection to investigate ...
Diana Inkpen +7 more
core +3 more sources