Results 81 to 90 of about 410,068 (315)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Video retrieval using dialogue, keyframe similarity and video objects [PDF]

, 2005
There are several different approaches to video retrieval which vary in sophistication, and in the level of their deployment. Some are well-known, others are not yet within our reach for any kind of large volumes of video.
Paul Browne, Smeaton, Alan F., Browne, Paul, P. Browne, Alan F. Smeaton, A.F. Smeaton   +5 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Context guided retrieval

, 1997
This paper presents a hierarchical case representation that uses a context guided retrieval method The performance of this method is compared to that of a simple flat file representation using standard nearest neighbour retrieval.
Watson, Ian, Perera, Srinath
core  

Advanced content-based semantic scene analysis and information retrieval: the SCHEMA project [PDF]

, 2003
The aim of the SCHEMA Network of Excellence is to bring together a critical mass of universities, research centers, industrial partners and end users, in order to design a reference system for content-based semantic scene analysis, interpretation and ...
I. KOMPATSIARIS, LEONARDI, Riccardo, Casas, Josep R., E. IZQUIERDO, Leonardi, R., Kompatsiaris, Ioannis, O'Connor, Noel E., NOEL E. OCONNOR, Izquierdo, Ebroul, M. G. STRINTZIS, Migliorati, P., MIGLIORATI, Pierangelo, J. R. CASAS, Strintzis, Michael G.   +13 more
core   +1 more source

Efficient Satellite Image Retrieval Using Shearlet Transforms and Spiking Neurons-Based Liquid Autoencoder Model

IEEE Access
This paper introduces an innovative content-based image retrieval system for precise and effective retrieval of satellite images. The system integrates liquid autoencoders with shearlet transforms to derive robust feature representations from satellite ...
Sai Bhargav Kasetty, K. Rajakumar
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Interactive experiments in object-based retrieval [PDF]

, 2006
Object-based retrieval is a modality for video retrieval based on segmenting objects from video and allowing end-users to use these objects as part of querying.
Sorin Sav, O'Connor, Noel E., Noel E. O’Connor, Sav, Sorin Vasile, Hyowon Lee, Smeaton, Alan F., Gareth J. F. Jones, Lee, Hyowon, Jones, Gareth J.F., Alan F. Smeaton   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source