Results 141 to 150 of about 383,504 (342)

Challenges in lentiviral vector production: retro-transduction of producer cell lines

open access: yesFrontiers in Bioengineering and Biotechnology
The increasing demand for lentiviral vectors (LVs) has led to the development of several stable cell lines and production methods over the last 2 decades in order to increase titers and yields, reduce production costs and improve the safety of the vector
Maximilian Klimpel   +8 more
doaj   +1 more source

Tuning the Twist by Molecular Design: A New Strategy for Hexabenzocoronene‐Containing Helical Twistacene

open access: yesChemistry – A European Journal, EarlyView.
An efficient Scholl–based strategy enables precise control of the C–C bond to access the first hexabenzocoronene–containing helical twistacene (NG2). The resulting nanographene shows pronounced helical distortion, high stability, enhanced solubility, and promising redox and optoelectronic properties.
Juan P. Mora‐Fuentes   +8 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

open access: yesChemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Product‐Related CSR in the Digital Era: Communication Patterns That Drive Consumer Interactions on Social Media

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT To meet rising sustainability demands, companies increasingly use social media to communicate product‐related CSR initiatives. Consumers' interactions with these messages largely depend on the messages' perceived credibility. However, there remains limited understanding of how firms combine communication characteristics into distinct patterns ...
Judith Derenthal, Waldemar Toporowski
wiley   +1 more source

SÉRIE DE CASOS DE HAMARTOMA CÍSTICO RETRO‐RETAL: DO DIAGNÓSTICO AO TRATAMENTO

open access: diamond, 2018
Hugo Samartine   +6 more
openalex   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang   +9 more
wiley   +1 more source

Retro-Auricular Fistula [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1936
openaire   +2 more sources

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