Results 61 to 70 of about 383,504 (342)
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Frontiers in Human Neuroscience, 2018 Shifts of attention within working memory based on retroactive (retro-) cues were shown to facilitate performance in working memory tasks. Although posterior asymmetries in the EEG, such as the contralateral delay activity (CDA), have been used to study ...
Anna Göddertz +3 more
doaj +1 more source
Durable, Cost-Effective Pavement Markings Phase I: Synthesis of Current Research, June 2001 [PDF]
, 2001 Pavement marking technology is a continually evolving subject. There are numerous types of materials used in the field today, including (but not limited to) paint, epoxy, tape, and thermoplastic.
core
Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Greek Gods and Heroes in Contemporary Global Literature: Repetition or Reinterpretation of Myths?
Literatura i Kultura PopularnaStephen Fry, Madeline Miller, Jenifer Sait, Conn Iggulden, Natalie Haynes, Valerio Massimo Manfredi, and other household names in contemporary popular literature write stories paraphrasing Greek mythology.
Martin Kasarda
doaj +1 more source
eLife, 2019 The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER).
David W Morgens +19 more
doaj +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions of 4-silylated oxazoles [PDF]
, 2002 4-Silylated oxazoles have been shown to undergo inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions with electron-poor alkynes to generate polysubstituted furans.
Ducept, P.C., Marsden, S.P.
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PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Retro Design and Nostalgic Marketing: Influence of nostalgic trend in consumer behavior
Vértices, 2016 The presence of elements that refer to nostalgia in many sectors of contemporary society has been studied by researchers from various areas. In marketing, nostalgia is perceived as a market trend that attracts consumers through their past emotions.
Alline Sardinha Cordeiro Morais +3 more
doaj +1 more source