Results 41 to 50 of about 361,925 (266)

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Postoperative Pain and Healing in Patients Undergoing Apicoectomy: A Comparative Study of Techniques

Journal of Pharmacy and Bioallied Sciences
Introduction: Apicoectomy, a surgical procedure to remove the apex of a tooth, is used when conventional root canal treatment fails. Various techniques, such as root-end resection with or without retrograde fillings, influence postoperative outcomes like
Sneha A. Patil, Sunita Shivanand, Rukhsar Rizwan, Mohan K. R. Sirigiri, Pragnya Uppalapati, Hitesh Chohan, Abhishek Gaur   +6 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Success of Retrograde Filling Retreatments of Teeth with Intraradicular Restorations and Orthograde Restorations of Teeth with Periapical Lesions

Albanian Journal of Trauma and Emergency Surgery
Imtroduction: Endodontic treatment failure, primarily caused by persistent intracanal microorganisms, necessitates retreatment decisions between conservative orthograde approaches and surgical periapical interventions.
Seha Mustafai, Jetmire Alimani Jakupi, Armend Demiri, Amella Cana   +3 more
doaj   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

The Success rate of Retrograde Filling Materials in Re-apicectomized Teeth using Mineral Trioxide Aggregate (MTA) and Zinc free Amalgam (A comparative clinical study). [PDF]

Al-Rafidain Dental Journal, 2012
Aim of the study: To compare the success rate of root end filling material using MTA( mineral trioxide aggregate) and zinc free amalgam in re-apicectomized teeth. Materials and methods: The study sample consisted of 30 patients having previously failed
Bara S Minwah , Wael Sh Hussain, Hani M Khlaif   +2 more
doaj   +1 more source

Results retrograde root filling channel of a tooth varions materials [PDF]

, 2011
Use of retrograde filling to prevent reinfection periapical area, save the tooth if you can not pass a root canal on a full-length nedoplombirovannoy apical part. Dense obturation, the possibility of leakage of tissue fluid into the root canal depends on
Лящепкова, Е. Г., Костина, И. Н., Ioschenko, E. S., Shtencel, N. V., Kostina, I. N., Штенцель, Н. В., Lyascenkova, E. G., Иощенко, Е. С.   +7 more
core  

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

The alignment of ultrasonic root-end cavity preparations using an in situ cadaver model

Saudi Endodontic Journal, 2018
Aim: This study aims to compare the alignment of root-end cavities prepared with ultrasonic tips with the root canal outline in teeth with and without root canal fillings using an in situ cadaver model.
Abdullah Ali Al-Sharif, Essam Abdullah Almanea, Ibrahim Ali Ahmad   +2 more
doaj   +1 more source