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Paroxetine and Mortality in Heart Failure: A Retrospective Cohort Study
IntroductionParoxetine is a GRK2 inhibitor that has been widely used to treat depression and anxiety over the last few decades. The inhibition of GRK2 has been studied extensively in vivo; however, evidence of its impact on heart failure remains scarce ...
Hongxuan Xu+12 more
doaj +1 more source
Bloodstream infections (BSIs) represent a substantial mortality risk, yet most studies are limited to select pathogens or populations. The aim of this study was to describe the population-wide prevalence of BSIs and examine the associated mortality risk ...
Mark J. Verway+12 more
semanticscholar +1 more source
Objective To evaluate viral loads at different stages of disease progression in patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first four months of the epidemic in Zhejiang province, China.
Shufa Zheng+30 more
semanticscholar +1 more source
Background: Between February and June 2021, the initial wild-type strains of SARS-CoV-2 were supplanted in Ontario, Canada, by new variants of concern (VOCs), first those with the N501Y mutation (i.e., Alpha/B1.1.17, Beta/B.1.351 and Gamma/P.1 variants ...
D. Fisman, A. Tuite
semanticscholar +1 more source
Infective endocarditis: a retrospective cohort study [PDF]
Abstract Background Infective endocarditis (IE) is a potentially life-threatening infection of the heart’s endocardial surface. Despite advances in the diagnosis and management of IE, morbidity and mortality remain high.
S O'Rourke+11 more
openaire +2 more sources
Introduction Apremilast, the first oral targeted treatment for moderate to severe psoriasis, is associated with diarrhea, nausea, and vomiting, which have contributed to treatment discontinuation.
Lana Schmidt+6 more
doaj +1 more source
Cohort Studies: Prospective versus Retrospective [PDF]
Cohort studies form a suitable study design to assess associations between multiple exposures on the one hand and multiple outcomes on the other hand. They are especially appropriate to study rare exposures or exposures for which randomization is not possible for practical or ethical reasons.
Carmine Zoccali+3 more
openaire +3 more sources
Tuberculosis in the ICU: a retrospective cohort study [PDF]
To describe the characteristics of the patients with tuberculosis (TB) requiring intensive care and to identify the factors associated with in-hospital mortality in an ICU in Portugal.
Lurdes Santos+6 more
openaire +2 more sources
Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort study
Introduction Randomised controlled trials have shown that steroids reduce the risk of dying in patients with severe Coronavirus disease 2019 (COVID-19), whilst many real-world studies have failed to replicate this result. We aim to investigate real-world
Wenjuan Wang+8 more
doaj +1 more source
Much attention has been paid to conversion therapy for stage IV gastric cancer, however, its operative comorbidities and survival benefit have not yet been clarified.
Kazuhiro Yoshida+16 more
semanticscholar +1 more source