Results 41 to 50 of about 1,246,243 (313)

Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia [PDF]

, 2015
BACKGROUND: Cervical intra-epithelial neoplasia (CIN) typically occurs in young women of reproductive age. Although several studies have reported the impact that cervical conservative treatment may have on obstetric outcomes, there is much less evidence
Acharya, Albrechtsen, Anderson, Arbyn, Arbyn, Arbyn, Arbyn, Armarnik, Begg, Berretta, Bigrigg, Blomfield, Braet, Bruinsma, Bruinsma, Buller, Castanon, Castanon, Chew, Cochran, Conner, Cruickshank, Deeks, Dersimonian, Egger, Ferenczy, Forsmo, Founta, Frega, Gordon, GRADE Working Group 2004 GRADE Working Group, Haffenden, Hagen, Hammond, Heinonen, Higgins, Holmes, Holmes, Human Microbiome Project Consortium, Jakobsson, Jiménez, Jones, Kalliala, Kalliala, Keijser, Kennedy, Khalid, Kitchener, Kuoppala, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Larsson, Li, Luesley, Macvicar, Martin-Hirsch, Mathevet, Mazouni, Michelin, Moher, NHS Cervical Screening Programme, Nicholson, Noehr, Nuovo, Paraskevaidis, Paraskevaidis, Paraskevaidis, Phadnis, Philipp, Prendiville, Quinn, Raio, Ravel, Sagot, Shanbhag, Sjøborg, Soutter, Spitzer, Spracklen, Steichen, Strander, Stroup, Suarez, Tan, Turlington, Vijver, Weber   +89 more
core   +1 more source

IgG4-related hypophysitis: a retrospective cohort study

Acta Neurochirurgica, 2022
AbstractPurposeIgG4-related hypophysitis (IgG4-RH) is a rare chronic inflammatory condition of the pituitary gland. This study reports the presentation, management and outcomes for patients with histologically proven IgG4-related hypophysitis.MethodsA prospectively maintained electronic database was searched over a 14-year period from 1 January 2007 to
R. Bhargava, Z. Hussein, N. L. Dorward, J. P. Grieve, Z. Jaunmuktane, H. J. Marcus, I. Proctor, S. E. Baldeweg   +7 more
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Associations between anthropometric characteristics and physical performance in male law enforcement officers: A retrospective cohort study [PDF]

, 2016
BACKGROUND: Police officers are often required to undertake physically demanding tasks, like lifting, dragging and pursuing a suspect. Therefore, physical performance is a key requirement. METHODS: Retrospective data for 76 male police officers (mean age 
Dawes, James Jay, Orr, Robin Marc, Pope, Rodney, Siekaniec, Claire Louise, Vanderwoude, Andrea Annie   +4 more
core   +2 more sources

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Treatment of the Fractional Curve of Adult Scoliosis With Circumferential Minimally Invasive Surgery Versus Traditional, Open Surgery: An Analysis of Surgical Outcomes. [PDF]

, 2018
Study Design:Retrospective, multicenter review of adult scoliosis patients with minimum 2-year follow-up. Objective:Because the fractional curve (FC) of adult scoliosis can cause radiculopathy, we evaluated patients treated with either circumferential ...
Anand, Neel, Chou, Dean, Deviren, Vedat, Eastlack, Robert, Fessler, Richard, Fu, Kai-Ming, International Spine Study Group, Kanter, Adam, La Marca, Frank, Mummaneni, Praveen, Mundis, Gregory, Nguyen, Stacie, Nunley, Pierce, Okonkwo, David, Park, Paul, Than, Khoi, Uribe, Juan, Wang, Michael, Zavatsky, Joseph   +18 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Implant Treatment in the Predoctoral Clinic: A Retrospective Database Study of 1091 Patients [PDF]

, 2016
Purpose: This retrospective study was conducted at the Marquette University School of Dentistry to (1) characterize the implant patient population in a predoctoral clinic, (2) describe the implants inserted, and (3) provide information on implant ...
Bansal, Naveen K., Hambrook, Christopher, Hefti, Arthur F., Prasad, Soni, Reigle, Eric, Sherman, Katherine   +5 more
core   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

When should a child with an undescended testis be referred to a urologist? [PDF]

, 2006
Infants with an undescended testis should be referred between ages 6 and 15 months, since almost all who experience spontaneous descent do so by 6 months (strength of recommendation [SOR]: A, extrapolation from cohort studies). The incidence of germ cell
Bishop, Rachel, Kelsberg, Gary, Morton, Jacquelyn R.   +2 more
core