Results 51 to 60 of about 1,246,243 (313)

The Improvement of Laparoscopic Surgical Skills Obtained by Gynecologists after Ten Years of Clinical Training Can Reduce Peritoneal Adhesion Formation during Laparoscopic Myomectomy: A Retrospective Cohort Study [PDF]

, 2017
Objective. To evaluate if improvement of laparoscopic skills can reduce postoperative peritoneal adhesion formation in a clinical setting. Study Design. We retrospectively evaluated 25 women who underwent laparoscopic myomectomy from January 1993 to June
Mais, Valerio, Minerba, Luigi, Peiretti, Michele   +2 more
core   +3 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Safety of medication use in primary care [PDF]

, 2015
© 2014 Royal Pharmaceutical Society.BACKGROUND: Medication errors are one of the leading causes of harmin health care. Review and analysis of errors have often emphasized their preventable nature and potential for reoccurrence.
Abramson, Abramson, Adubofour, Ahmad, Al Khaja, Al Khaja, Alldred, Alldred, Aronson, Aronson, Ashcroft, Avery, Avery, Avery, Barber, Bayoumi, Berner, Bernstein, Beso, Boockvar, Boockvar, Booij, Braund, Bregnhoj, Britt, Brown, Buurma, Campbell, Carruthers, Chen, Chua, Coleman, Dallenbach, Dean, Dean, Dean, Dean Franklin, Dean Franklin, Department of Health, Department of Health, Department of Health, Devine, Dhabali, Eslami, Field, Fischer, Flynn, Gagne, Gandhi, Gandhi, Gandhi, Garfield, Ghaleb, Ginzburg, Glassman, Green, Gurwitz, Hazlet, Howard, Hume, Humphries, Hämmerlein, Janice O. Olaniyan, Kaushal, Kaushal, Kennedy, Khoja, Knudsen, Knudsen, Kohn, Kuo, Lafata, Lasser, Leape, Lemer, Lewis, Lisby, Lopez-Picazo, Lynskey, Maisoon Ghaleb, Martínez Sánchez, Marwaha, Miller, Moniz, Nanji, Nemeth, Norden-Hagg, Palen, Paul Robinson, Pirmohamed, Raebel, Reason, Royal, Runciman, Sarvadikar, Sayers, Shah, Singh, Soraya Dhillon, Sorensen, Stefanovic, Sweidan, Szczepura, Tam, Tamblyn, Teinilä, Thomsen, Varkey, Vincent, Warholak, Wetzels, Wild, Wong, World Health Organisation   +113 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

The two-stage clonal expansion model in occupational cancer epidemiology: Results from three cohort studies [PDF]

, 2010
Copyright © 2010 by the BMJ Publishing Group Ltd. All rights reserved.Objectives: The objective of this work was to apply the two-stage clonal expansion model, with the intention to expand the literature on epidemiological applications of the model and ...
Gore, R, Kriebel, D, Zeka, A
core   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Epidemiology of anaphylaxis: A retrospective cohort study in Taiwan

Asian Journal of Anesthesiology, 2017
Medication-induced anaphylaxis is a potentially fatal event. Little is known at present about the patterns of medication-induced anaphylaxis in Asian countries. The current study aims to examine the pattern of documented incidences of drug-associated anaphylaxis in Taiwan over a 9-year period.Cases of medication-associated anaphylaxis documented in the
Wei-Zen Sun, Yow-Shan Lee
openaire   +3 more sources

Antifungal Resistance in Patients with Candidemia: A Retrospective Cohort Study [PDF]

BMC Infectious Diseases, 2019
Abstract Background: Candidaemia is the most common form of invasive candidiasis. Resistant Candida blood stream infection (BSI) is rising , with limitations on the development of broader-spectrum antifungal agents worldwide. Our study aimed to identify the occurrence of antifungal-resistant candidaemia and the distribution of these species ...
Namareq Aldardeer, Hadiel Albar, Majda Al-Attas, Abdelmoneim Eldali, Mohammed Qutub, Ashraf Hassanien, Basem Alraddadi   +6 more
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Relationship between cardiovascular risk and lipid testing in one health care system: a retrospective cohort study. [PDF]

, 2015
BackgroundThe US Preventive Services Taskforce (USPSTF) recommends routine lipid screening beginning age 35 for men [1]. For women age 20 and older, as well as men age 20-34, screening is recommended if cardiovascular risk factors are present.
Anderson, Melissa L, Catz, Sheryl L, Fishman, Paul A, Green, Beverly B, Johnson, Ron L, McClure, Jennifer B, Reid, Robert J   +6 more
core   +1 more source