Results 281 to 290 of about 44,030,521 (374)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Relationship between antihyperglycemic drugs and Myocardial Infarction in the elderly - A retrospective study.

, 1984
Teruyuki Itagaki
openalex   +2 more sources

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source

Relationship between diabetes mellitus and cerebral infarction particularly regarding treatment in the elderly. A retrospective study.

, 1987
Teruyuki Itagaki, Masaru Haruyama, Ryouichi Yoshida, Takaomi Suzuki, Michio Hayakawa, E Otomo, H Hannya   +6 more
openalex   +2 more sources

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Relation between the state at perinatal term, condition of bringing up as well as development at 4 and at 10 months old and speech delay at 18 months old - Retrospective study on delayed speech children found at the time of group health exmination for 18 months old children.

, 1986
Fujiko Konjiki
openalex   +2 more sources

The early mortality rate of people infected with coronavirus (COVID-2019) in Wuhan, China: Review of three retrospective studies.

J Pharm Bioallied Sci, 2020
Elnour AA, Don J, Yousif I, Gnana K, Abdi S, Alhajri N, Al Amoodi A, Fathelrahman AI, Mohammed Magboul S, Mohamed S, Ahmed SA, Sadeq A.   +11 more
europepmc   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

A retrospective study on 12 cases of cancer of the lip.

, 1987
Ken-ichi NOTANI, Motoaki HANZAWA, Tetsuro YAMASHITA, Yasunori Totsuka, Hiroshi Fukuda   +4 more
openalex   +2 more sources

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source