Results 61 to 70 of about 43,695,403 (371)

Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment

JAMA psychiatry, 2019
Key Points Question What is the agreement between prospective and retrospective measures of childhood maltreatment? Findings This systematic review and meta-analysis of 16 unique studies and 25 471 unique participants found poor agreement between ...
J. Baldwin, Aaron Reuben, J. Newbury, A. Danese   +3 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Retrospective-prospective symmetry in the likelihood and Bayesian analysis of case-control studies

, 2013
Prentice & Pyke (1979) established that the maximum likelihood estimate of an odds-ratio in a case-control study is the same as would be found by running a logistic regression: in other words, for this specific target the incorrect prospective model is ...
Byrne, Simon P. J., Dawid, A. Philip
core   +1 more source

Poisoning Cases Admitted to the Pediatric Emergency Department: A Retrospective Evaluation

Journal of Pediatric Emergency and Intensive Care Medicine, 2022
Introduction:Intoxication in childhood is an important preventable public health problem and can cause morbidity and mortality. In this study, we investigated the clinical and demographic characteristics of patients who presented to our pediatric ...
Yusuf Güzel, Fatih Battal, Hakan Aylanç   +2 more
doaj   +1 more source

Effects of Massive Transfusion Protocol Implementation in Trauma Patients at a Level I Trauma Center [PDF]

Journal of Trauma and Injury, 2020
Purpose This study was conducted to investigate whether rapid and efficient administration of blood products was achieved and whether clinical outcomes were improved by applying a massive transfusion protocol (MTP). Methods From January 2016 to September
Hyun Woo Sun, Sang Bong Lee, Sung Jin Park, Chan Ik Park, Jae Hun Kim   +4 more
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Titanium versus absorbable tacks comparative study (TACS): a multicenter, non-inferiority prospective evaluation during laparoscopic repair of ventral and incisional hernia: study protocol for randomized controlled trial [PDF]

, 2015
BACKGROUND: Laparoscopic repair of ventral and incisional hernias has gained popularity since many studies have reported encouraging results in terms of outcomee and recurrence.
Baldazzi, G, Campanile, Fc, Cavallaro, Giuseppe, Olmi, S, Raparelli, L, Silecchia, Gianfranco   +5 more
core   +1 more source

A critical analysis of the decreasing trends in tuberculosis cure indicators in Brazil, 2001-2022 [PDF]

Jornal Brasileiro de Pneumologia
Objective: To analyze the temporal trend of tuberculosis cure indicators in Brazil. Methods: An ecological time-series study using administrative data of reported cases of the disease nationwide between 2001 and 2022.
Gabriel Pavinati, Lucas Vinícius de Lima, Pedro Henrique Paiva Bernardo, Jhenicy Rubira Dias, Bárbara Reis-Santos, Gabriela Tavares Magnabosco   +5 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source