Results 71 to 80 of about 2,068,929 (319)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Drug use evaluation: A two‐year retrospective review of the effectiveness and tolerability of agomelatine versus mirtazapine in patients with depressive disorder

Brain and Behavior, 2021
Objective To compare the effectiveness and tolerability of agomelatine with mirtazapine in patients with depressive disorder. To illustrate the prescribing pattern of agomelatine and identify factors that affect the pattern of treatment result and ...
Shek Ming Leung
doaj   +1 more source

Hermite functions with discontinuous coefficients for the solution of fractal diffusion retrospective problems [PDF]

arXiv, 2013
In this article we study the retrospective inverse problem. The retrospective inverse problem consists of in the reconstruction of a priori unknown initial condition of the dynamic system from its known final condition. Existence and uniqueness of the solution is proved.
arxiv  

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Elevated Risk of Stroke in Young Adults After Traumatic Brain Injury: A Nationwide Study of 1 Million Individuals

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Although stroke is commonly perceived as occurring in older adults, traumatic brain injury, one of the risk factors for stroke, is a leading cause of death in the younger adults.
Yoonjeong Choi, Jooeun Jeon, Eun Jin Ha, Chi Kyung Kim, Han Gil Seo, Byung‐Mo Oh, Ja‐Ho Leigh   +6 more
doaj   +1 more source

Poisoning Cases Admitted to the Pediatric Emergency Department: A Retrospective Evaluation

Journal of Pediatric Emergency and Intensive Care Medicine, 2022
Introduction:Intoxication in childhood is an important preventable public health problem and can cause morbidity and mortality. In this study, we investigated the clinical and demographic characteristics of patients who presented to our pediatric ...
Yusuf Güzel, Fatih Battal, Hakan Aylanç   +2 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Odontogenic infections in a dental emergency care unit: Eleven-year epidemiological analysis

Brazilian Journal of Oral Sciences, 2017
Aim: To evaluate medical records from patients who underwent abscess drainage due to odontogenic infections in a public hospital in the city of Belo Horizonte (Minas Gerais, Brazil) during the period of 2003 and 2013. Methods: A retrospective analysis of
Antônio Luis Neto Custódio, Raphael Márcio Egídio Cota, Leandro Junqueira de Oliveira   +2 more
doaj   +1 more source

Maxillofacial infection. A retrospective evaluation of eight years

Brazilian Journal of Oral Sciences, 2015
Aim: To evaluate medical records from patients who had maxillofacial infections between August 2002 and May 2010. Methods: Analysis of 157 patients’ data looking for epidemiology, causes of the infection, type of treatment established and complications ...
Bruno Veronez, Fernando Pando de Matos, Marcelo Silva Monnazzi, Alexander Tadeu Sverzut, Cássio Edvard Sverzut, Alexandre Elias Trivellato   +5 more
doaj   +1 more source