Results 251 to 260 of about 3,101,407 (362)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Relation between the state at perinatal term, condition of bringing up as well as development at 4 and at 10 months old and speech delay at 18 months old - Retrospective study on delayed speech children found at the time of group health exmination for 18 months old children.

, 1986
Fujiko Konjiki
openalex   +2 more sources

Interpretable Multimodal Fusion Model Enhances Postoperative Recurrence Prediction in Gastric Cancer

Advanced Science, EarlyView.
An interpretable multimodal fusion model (RSA) integrating clinical, radiomic, and pathomic features is developed and validated to predict early postoperative recurrence in gastric cancer. The RSA model demonstrates superior predictive performance and holds potential for guiding adjuvant chemotherapy decisions and improving individualized patient ...
Ping'an Ding, Jiaxuan Yang, Sheng Chen, Honghai Guo, Jiaxiang Wu, Haotian Wu, Li Yang, Wenqian Ma, Yuan Tian, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Yueping Liu, Lingjiao Meng, Qun Zhao   +16 more
wiley   +1 more source

Impact of Diabetes on Clinical Characteristics and Prognosis in Sepsis: A Retrospective Study. [PDF]

J Inflamm Res
Han WW, Fang JJ.
europepmc   +1 more source

A retrospective study on 12 cases of cancer of the lip.

, 1987
Ken-ichi NOTANI, Motoaki HANZAWA, Tetsuro YAMASHITA, Yasunori Totsuka, Hiroshi Fukuda   +4 more
openalex   +2 more sources

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

The retrospective study of neurogenic hypernatremia in general ICU.

, 1986
T Uefuji, A Yokono, Y Tosaki, Yoichi Shirakawa, Kenji Oguli   +4 more
openalex   +2 more sources

SCORCH2: A Generalized Heterogeneous Consensus Model for High‐Enrichment Interaction‐Based Virtual Screening

Advanced Science, EarlyView.
Researchers developed SCORCH2, an advanced machine‐learning scoring function for virtual screening that combines two complementary XGBoost models to re‐evaluate protein‐ligand binding plausibility. The method demonstrates superior performance on standard benchmarks, shows excellent generalization to previously unseen protein targets, and provides ...
Lin Chen, Vincent Blay, Pedro J. Ballester, Douglas R. Houston   +3 more
wiley   +1 more source