Results 61 to 70 of about 2,148,186 (263)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

A Simultaneous Control, Localization, and Mapping System for UAVs in GPS-Denied Environments

open access: yesDrones
Unmanned Aerial Vehicles (UAVs) have gained significant attention due to their versatility in applications such as surveillance, reconnaissance, and search-and-rescue operations.
Rodrigo Munguia   +3 more
doaj   +1 more source

Flood volume allocation method for flood hazard mapping using river model with levee scheme [PDF]

open access: yesGeoscientific Model Development
A realistic flood risk assessment is important for rivers where the flood protection infrastructures are dictated by varying return periods. For rivers in Japan, design return periods for flood protection infrastructures range up to 200 years.
M. H. Aslam   +6 more
doaj   +1 more source

Singapore 1:25,000 road map [cartographic material] /

open access: yes, 1980
Ed. 3 SMU. Shows selected buildings, points of interest, and schools.; Base information, aerial photography dated Jan. 1974, Aug. 1979 and partial ground verification up to Jan. 1980.; "R.S.O. metric grid."; Some sheets include insets.; Includes lists of
Singapore. Ministry of Defence. Mapping Unit.
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Mapping Wildfire Ignition Probability Using Sentinel 2 and LiDAR (Jerte Valley, Cáceres, Spain)

open access: yesSensors, 2018
Wildfire is a major threat to the environment, and this threat is aggravated by different climatic and socioeconomic factors. The availability of detailed, reliable mapping and periodic and immediate updates makes wildfire prevention and extinction work ...
Yolanda Sánchez Sánchez   +3 more
doaj   +1 more source

Urandangi, Queensland [cartographic material] /

open access: yes, 1951
1st ed. Topographic map of Urandangi region, Queensland, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, windpumps, and bore, tank and well classifictions. Relief shown by hachures and spot heights.;
Australia. National Mapping Section.
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Avon Downs, Northern Territory [cartographic material] /

open access: yes, 1952
1st ed. Topographic map of Avon Downs region, Northern Territory, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, windpumps, and bore, tank and well classifictions.
Australia. National Mapping Section.
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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