Results 51 to 60 of about 173,454,649 (206)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Clinical outcomes of patients with in-hospital witnessed cardiac arrest: effect of co-morbidities

Egyptian Journal of Critical Care Medicine
Introduction Cardiopulmonary resuscitation (CPR) is frequently performed in hospitalized patients after in-hospital cardiac arrest (IHCA), especially in the intensive care unit (ICU) (J Crit Care 24:408-414, 2009).
Yasser Nassar, Sozan Fathy, Sherif Sabri, Ayman Gaber, Sherif Mokhtar   +4 more
doaj   +1 more source

Predictors of resuscitation in a swine model of ischemic and nonischemic ventricular fibrillation cardiac arrest : superiority of amplitude spectral area and slope to predict a return of spontaneous circulation when resuscitation efforts are prolonged

, 2010
We have demonstrated that a return of spontaneous circulation in the first 3 mins of resuscitation in swine is predicted by ventricular fibrillation waveform (amplitude spectral area or slope) when untreated ventricular fibrillation duration or presence ...
Ronald W. Hilwig, Shanmugasundaram, Madhan, Robert A. Berg, Hilwig, Ronald W., Madhan Shanmugasundaram, Kern, Karl B., Julia H. Indik, Karl B. Kern, Berg, Robert A., Daniel Allen, Mathias Zuercher, Zuercher, Mathias, Indik, Julia H., Allen, Daniel   +13 more
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

One oxygen breath shortened the time to return of spontaneous circulation in severely asphyxiated piglets

, 2017
Aim: Asphyxiated neonates should be resuscitated with air, but it remains unclear if oxygen supplementation is needed in ineffectively ventilated newborn infants.
Cunha-Goncalves, Doris, Valeria Perez-de-Sa, Doris Cunha-Goncalves, Linner, Rikard, Rikard Linner, Perez-de-Sa, Valeria, Perez-de-Sa, Valeria,, Lund University., Linner, Rikard,, Cunha-Goncalves, Doris,   +9 more
core   +1 more source

Patient flow diagram.

, 2022
ROSC: Return of spontaneous circulation; CA: Cardiac arrest; CT: Computed tomography.
Marine Paul (11696852), Hugo Bellut (7912109), Stéphane Legriel (6717215), Sybille Merceron (6717209), Jean-Pierre Bedos (307594), Alain Cariou (2286), Florence Dumas (5185859), Sarah Benghanem (11206354), Amandine Henry (13155143), Fabrice Bruneel (240159)   +9 more
core   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Increased abdominal fat accumulation is associated with decreased survival to hospital admission in out-of-hospital cardiac arrest: a single center retrospective study

Resuscitation Plus
Objective: The impact of obesity on outcomes after out-of-hospital cardiac arrest (OHCA) remains controversial. This study aimed to evaluate the association between abdominal fat accumulation, quantified by computed tomography (CT), and outcomes in ...
Yasutaka Koga, Motoki Fujita, Ryo Ayata, Tomoaki Inoue, Takeshi Yagi, Masaki Todani, Kotaro Kaneda, Ryosuke Tsuruta   +7 more
doaj   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source