Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
MAXIMIZING THE PRODUCTIVITY AND WATER USE EFFICIENCY OF TOMATO PLANTS (LYCOPERSICON ESCULENTUM MILL.) CULTIVATED IN THE NEW RECLAIMED LANDS USING DIFFERENT IRRIGATION WATER QUANTITIES AND SOME WATER SAVING SUBSTANCES [PDF]
Egypt is one of the countries facing great challenges due to its limited water resources, so it has become necessary to study the best ways to rationalize irrigation water use and maximizing the efficient use of water under those circumstances. Two field
M. El-Shazly, A. Kamal
doaj +1 more source
Leaves from the diary of a Van Diemen's land official
Before I ring up the curtain, and bring before the footlights the characters who played their parts upon the little Stage of Van Diemen's Land Society of the first half of last century, described for us with such fidelity in the pages of the Diarist ...
W. Hudspeth
semanticscholar +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
As customized artistic commodities, export paintings mirrored Guangzhou's unique overseas trade culture and social power in a microscopic view, nevertheless, few researchers have delved into the cultural relationship between the use of the painting ...
Haisa Liu, Changqing Fu, Weicong Li
doaj +1 more source
The Intellectual’s Duality: The African Female Intellectual between Home and Abroad in Chimamanda Ngozi Adichie’s Americanah and Sefi Atta’s A Bit of Difference ثنائية المفكر: المثقفة الأفريقية بين الوطن والهجرة في روايتي أمريكانا لشيمامندا نجوزي اديشي وقليلا من الاختلاف لسيفي أتا [PDF]
SummaryThis research analyses Chimamanda Adichie’s Americanah (2013) and A Bit of Difference by Sefi Atta (2012), in order to reflect the idea of migration and the experiences of two female intellectuals in a transcultural world.
راجية السعيد أبو النصر
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On June 13, 2003 the NASA Administrator appointed two vetereran astronauts to lead an external task group in an independent assessment of the agency's "Return to Flight" efforts and to help the nation return the Space Shuttle safely to flight. On August
Return to Flight Task Group
core
A Return to Linnaeus’s Focus on Diagnosis, Not Description: The Use of DNA Characters in the Formal Naming of Species [PDF]
Descriptions and diagnoses are alternative choices in all Codes of Nomenclature because Linnaeus relied on diagnoses, not descriptions, to name ca. 13,400 animals, plants, and fungi. A diagnosis names characters in which a new taxon differs from the most similar known taxon; a description mixes taxonomically informative and uninformative features ...
openaire +2 more sources

