Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia +29 more
wiley +1 more source
Generalized Robust Optimization using the Notion of Set-Valued Probability. [PDF]
Torre D, Mendivil F, Rocca M.
europepmc +1 more source
PENGARUH RETURN ON ASSET, RETURN ON EQUITY DAN EARNING PER SHARE TERHADAP RETURN SAHAM PEMBENTUK INDEKS KOMPAS 100 [PDF]
Dedi Hariyanto, Abdurrahman Abdurrahman
openalex +1 more source
Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source
Association of risk management practices and financial performance of microfinance institutions in Ethiopia: A two-step system generalized method of moments approach. [PDF]
Molla MT, Kaur R.
europepmc +1 more source
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen +9 more
wiley +1 more source
Optimising housing typology distributions for multi-hazard loss reductions in resource-constrained settings. [PDF]
Hadlos A, Opdyke A, Hadigheh SA.
europepmc +1 more source
Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu +8 more
wiley +1 more source
Measurement model of credit risk for unlisted agricultural enterprises. [PDF]
Liang K, Chen Y, Guo T, He T.
europepmc +1 more source

