Results 241 to 250 of about 938,873 (282)

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells

Advanced Science, EarlyView.
This study identifies akermanite among six bioceramics and reveals its ability to enhance Schwann cell's proliferation, migration, and secretion. When combined with silk sericin, the composite conduit synergistically enhances Schwann cell‐mediated regenerative processes.
Qiangfei Su, Jian Wang, Yu Song, Zhaowenbin Zhang, Bo Cai, Xiakeerzhati Xiaohalati, Jingwei Liu, Haozhe Li, Zheng Wang, Jiang Chang, Lin Wang   +10 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Revealing a Pathway for Low‐Temperature Recrystallization in Germanium

Advanced Science, EarlyView.
This study reports the discovery that energy transferred to electrons and atoms by highly ionizing ions results in a disorder‐order (amorphous‐crystalline) phase transformation in noncrystalline (amorphous) Ge. This discovery unlocks low‐temperature recrystallization pathways in Ge, offering a nonthermal strategy for fabricating Ge‐based devices that ...
Gihan Velişa, Eva Zarkadoula, Decebal Iancu, Maria D. Mihai, Alexandre Boulle, Yang Tong, Da Chen, Yanwen Zhang, William J. Weber   +8 more
wiley   +1 more source

Effect of Firm Attributes on Return on Asset of Listed Manufacturing Companies in Nigeria

, 2018
Irom Marvis Irom, Joshua Okpanachi, M. Nma Ahmed, Adewale Emmanuel   +3 more
openalex   +1 more source

Programmable and Reversible 3D‐to‐3D Shape Transformation: Hierarchical Multimodal Morphing Based on Liquid Crystal Elastomers

Advanced Science, EarlyView.
Hierarchical multimodal 3D‐to‐3D shape morphing is achieved in liquid crystal elastomer‐elastomer bilayers via programmable mismatch strains. Combining pre‐stretch and thermal actuation enables reversible transformations with non‐zero Gaussian curvature, empowering over 30 complex configurations for biomimetic camouflage, adaptive robotics, and dynamic
Jiayu Tian, Chuanqian Shi, Guohua Nie, Chenzhe Li, Ying Zhao   +4 more
wiley   +1 more source

SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice

Advanced Science, EarlyView.
The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu, Niannian Chen, Xiaowei Fan, Xueqing Xia, Yilong Yao, Wen Huang, Jin Sun, Lintao Huang, Lei Wang, Hong Yu, Jiayang Li, Yongzhong Xing   +11 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

Advanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang, Yuxiao Wang, Yang Ding, Xiang Chen, Shuhan Li, Wenqi Zhou, Rui Ma, Maomao Tang, Xinyuan Shao, Zixuan Shu, Ning He, Xiaodong Ma, Jian Guo, Chengjun Peng, Shuangying Gui   +14 more
wiley   +1 more source

Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma

Advanced Science, EarlyView.
BRAF/MEK inhibition promotes extracellular matrix (ECM) accumulation and remodeling during therapy‐tolerant residual disease, limiting CD8⁺ T cell access to tumor cells. Targeting ECM accumulation restores CD8⁺ T cell infiltration, enhances their intratumoral distribution, and delays therapeutic resistance.
Chia‐Hsin Hsu, Jingyi Chen, Keng‐Jung Lee, Leanne R. Donahue, Danielle Kacaj, Sean P. McDonough, Andrew C. White   +6 more
wiley   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

Hinst: Human‐Like Interactive Instinct Enables Robots to Robustly Accomplish Universal Tasks

Advanced Science, EarlyView.
Aiming at current robot limitations of poor flexibility, poor practicality, and poor universality in task accomplishment, the authors report a human‐like interactive instinct (Hinst) and an anthropomorphic robotic system architecture. The Hinst greatly enhances the efficiency and the success rate of robotic manipulation, skill learning, and task ...
Zijian Liao, Qian Mao, Yichen Qin, Jinfeng Yuan, Rong Zhu   +4 more
wiley   +1 more source