Results 311 to 320 of about 980,847 (378)

SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice

open access: yesAdvanced Science, EarlyView.
The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu   +11 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang   +14 more
wiley   +1 more source

Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma

open access: yesAdvanced Science, EarlyView.
BRAF/MEK inhibition promotes extracellular matrix (ECM) accumulation and remodeling during therapy‐tolerant residual disease, limiting CD8⁺ T cell access to tumor cells. Targeting ECM accumulation restores CD8⁺ T cell infiltration, enhances their intratumoral distribution, and delays therapeutic resistance.
Chia‐Hsin Hsu   +6 more
wiley   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi   +12 more
wiley   +1 more source

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