Results 61 to 70 of about 3,119,521 (274)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A 21-Gb/s Dual-Channel Voltage-Mode Transmitter With Stacked NRZ and PAM4 Drivers
IEEE Access, 2018 This paper describes a voltage-mode transmitter that stacks independent non-return-tozero (NRZ) and four-level pulse amplitude modulation (PAM4) drivers for dual channels.
Sung-Ha Kim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
AIP AdvancesHigh voltage circuit breakers are important equipment in power systems, and the valve motion of the chambers plays a role in the arc extinguishing performance of high-voltage circuit breakers. Therefore, in this paper, a 145 kV auto-expansion SF6 circuit
Ze Guo +4 more
doaj +1 more source
Dynamic Analysis of Power System with Photovoltaic Generation
MATEC Web of Conferences, 2016 With more penetration of solar power plants, photovoltaic generation will be exerting more influences on the power system. The main purpose of this paper is to study the dynamic characteristics of the power system with photovoltaic generation.
Hsu Chia-Yu +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Chengshi guidao jiaotong yanjiu[Objective] During the normal operation of metro lines, due to incomplete rail-ground insulation, metro that adopts AC (alternating current) traction power supply system can cause electromagnetic interference on adjacent metallic oil and gas pipelines ...
Yunyun ZHAO +5 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source