Results 191 to 200 of about 4,325 (265)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Delayed Neurological Sequelae of Carbon Monoxide Intoxication Initially Treated as Infectious Meningo Encephalitis. [PDF]

Eur J Case Rep Intern Med
Jannot X, Diallo AO, Didierjean J, Terrade JE, Andrès E, Feuermann M, Lorenzo-Villalba N.   +6 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

History Revaluated

Libri et Liberi, 2017
openaire   +1 more source

<i>KMT2B</i>-related disorders in Austria: clinical features and long-term outcome after deep brain stimulation. [PDF]

Front Neurol
Indelicato E, Siegert S, Langer A, Hussl A, Mahlknecht P, Mair K, Eberl A, Zech M, Schmidt WM, Boesch S.   +9 more
europepmc   +1 more source

Digital five-step questionnaire to enhance standard perioperative prophylaxis in surgical patients with reported allergy to beta-lactam-antibiotics. [PDF]

Antimicrob Steward Healthc Epidemiol
Röder D, Eichhorn K, Stoevesandt J, Stumpner J, Meybohm P, Surat G.   +5 more
europepmc   +1 more source

Sequential gastric and ileal perforations, a rare presentation in a man with sickle cell anemia: A case report. [PDF]

J Int Med Res
Ashindoitiang JA, Nwagbara VI, Magam DN, Nnalue VD, Asuquo ME.   +4 more
europepmc   +1 more source

Oral Angiolymphoid Hyperplasia With Eosinophilia Exhibiting Cutaneous-Type Histopathologic Features: Clinical Regression Following Hormonal Withdrawal and a 50-Year Review. [PDF]

J Cutan Pathol
Jesus PVS, Santos LC, Aciole GTDS, Cunha JLS, Lonni N, Costa MADS, Rivero ERC, Gondak R, Albuquerque-Júnior RLC.   +8 more
europepmc   +1 more source

Tonic pain revalues associative memories of phasic pain

Hewitt D, Tong S, Schreiber S, Seymour B.   +3 more
europepmc   +1 more source