Results 61 to 70 of about 57,509 (260)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Revascularization in Severe Left Ventricular Dysfunction: Does Myocardial Viability Even Matter?

, 2015
Left ventricular dysfunction is a powerful prognostic predictor in patients with coronary artery disease and increasing number of patients with CAD and ischemic left ventricular (LV) dysfunction is a major clinical problem.
Hani Kozman, Nishant Sethi, Navneet Kaur, Pahul Singh   +3 more
core   +1 more source

Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization: Fifty Years of Revascularization: Where Are We and Where Are We Heading? [PDF]

, 2015
The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various ...
Windecker, Stephan, Costa, F. (Francesco), Windecker, S.W. (Stephan), Kolh, Philippe, Ariotti, S. (Sara), Sara Ariotti, Kolh, P.H. (Philippe), Costa, Francesco, Marco Valgimigli, null null, Francesco Costa, Stephan Windecker, Valgimigli, M. (Marco), Philippe Kolh, Ariotti, Sara, Valgimigli, Marco   +15 more
core   +2 more sources

Impact of coronary revascularization on clinical outcomes of postacute myocardial infarction patients with left ventricular thrombus

Research and Practice in Thrombosis and Haemostasis
Background: The incidence of left ventricular thrombus (LVT), a significant complication postacute myocardial infarction (AMI), has seen a decline in the percutaneous coronary intervention era.
Andre Wen–Jie Seah, Aloysius Sheng–Ting Leow, Fang–Qin Goh, Benjamin Yong–Qiang Tan, Leonard Leong–Litt Yeo, William K.F. Kong, Kian–Keong Poh, James W.L. Yip, Raymond Ching–Chiew Wong, Ping Chai, Tiong–Cheng Yeo, Mark Yan–Yee Chan, Xin Zhou, Gregory Y.H. Lip, Ching–Hui Sia   +14 more
doaj   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Pullback pressure gradient: A paradigm shift in physiology-guided revascularization

Optimizing decision-making remains essential in the management of stable coronary artery disease (CAD). Recent studies of the pullback pressure gradient (PPG), a novel tool for evaluating CAD patterns, have demonstrated that the effectiveness of ...
Sakai, K., Kechichian, A., Mizukami, T., Collet, C., Bouisset, F., Spratt, J.C., Ikeda, K., Wyffels, E., Malhotra, G., Corradetti, S., Munhoz, D., Sonck, J., Wilgenhof, A., De Bruyne, B., Mahendiran, T.   +14 more
core   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Surveillance after distal revascularization for critical limb ischaemia

, 2012
Patients with critical limb ischaemia (CLI) are usually elderly and suffer from several co-morbidities. The goal of surveillance after both endovascular and surgical revascularization for CLI is not only the protection of re-established distal perfusion ...
Arvela, E, Dick, F
core   +1 more source

Incidence, Predictors, and Outcomes of Complete Angina Relief in Symptomatic Patients in the ISCHEMIA Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Patients with chronic coronary disease experience less angina with revascularization plus optimal medical therapy compared with optimal medical therapy alone.
Ayesha Singh, Jack C. S. Rodman, David L. Brown   +2 more
doaj   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source