Results 61 to 70 of about 174,272 (258)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Revealed comparative advantage index: an analysis of export trade in the Austrian district of Burgerland

open access: yesReview of Innovation and Competitiveness, 2016
The Austrian District of Burgenland is located in the eastern part of the country. In the last decade, the region has benefited from different subsidy programs from the European Union.
Doris Granabetter
doaj  

Revealed comparative advantages and regional specialization: Evidence from Colombia in the Pacific Alliance

open access: yesJournal of Applied Economics, 2019
This paper is a methodological contribution to the calculation and use of Revealed Comparative Advantage (RCA) indexes. We first explain why the RCA index of Contribution to the Trade Balance (CTB) is theoretically relevant. However, as other RCA indexes
Rémi Stellian, Jenny Danna-Buitrago
doaj   +1 more source

Botswana's revealed comparative advantage [PDF]

open access: yes, 2007
Analysis of Botswana’s competitiveness in world trade has been presented based on indices of revealed comparative advantage (RCA) calculated for the period 1999 and 2004. Results show that Botswana has RCA in diamonds, copper matte, and meat of bovine animals, among other products.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The tourism performance of spa destinations during crises in Central and Eastern Europe: An adjusted RCA index

open access: yesHeliyon
Tourism is affected by natural and man-made disasters, such as the recent COVID-19 pandemic and the Russia-Ukraine war. The impacts of these on tourism have been analysed at national and regional levels, and at the level of individual destinations ...
Zsuzsanna Bacsi   +2 more
doaj   +1 more source

ROMANIA’S SPECIALIZATION IN TRADE TOWARDS EU-27 - A REVEALED COMPARATIVE ADVANTAGE APPROACH [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2012
"International competitiveness" is a complex topic which raised over time many questions and theories on key factors that underpin it and is still subject to wide debate.
Popa Angela Cristina
doaj  

The factors of competitiveness and the quantification of their impact on the export efficiency of grape and wine in the Slovak Republic

open access: yesAgricultural Economics (AGRICECON), 2006
The paper devotes attention to evaluating the factors of competitiveness and the quantification of their impact on the export efficiency of grape and wine in the Slovak Republic.
M. Hambalková
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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