Results 41 to 50 of about 259,747 (341)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Personal experiences of Saint John portrayed in the Book of Revelation

Ruch Biblijny i Liturgiczny, 2005
The words of Apocalypse which Saint John wrote down in a singular number referring to himself can be focused on his sense of vision and of hearing as well as on his entire person.
Bogdan Zbroja
doaj   +1 more source

The Problem of Pentecostal and Charismatic Hermeneutics: Prophetic Reenactment as a Way Forward

Religions, 2023
To bridge gaps between Pentecostal and Charismatic hermeneutics, I will use two examples to propose a method, namely prophetic reenactment. First, the Azusa Street revival dramatically represented Acts 2, reflecting an interpretation of that chapter ...
Scott Storbakken
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ALISTER McGRATH AND EDUCATION IN SCIENCE AND RELIGION

Zygon, 2022
Alister McGrath has undoubtedly made an impressive contribution to educate people in science and religion, but what are the secrets of his success?
doaj   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Conceptualising holiness in the Gospel of John: The en route to and character of holiness (Part 2)

HTS Teologiese Studies/Theological Studies, 2017
In a previous publication, this author investigated the code as well as the objectives of holiness in the Gospel of John. This research deals with the en route to and character of holiness. The research starts with a concise characterisation of Jesus for
Dirk van der Merwe
doaj   +1 more source

Thomas Torrance\u27s Reformulation of Karl Barth\u27s Christological Rejection of Natural Theology [PDF]

, 2001
Karl Barth is widely noted for his antipathy to all forms of natural theology. Indeed, the results of Barth’s Christocentricity have made his name synonymous with the negation of all divine revelation apart from Christ, the one Word of God.
Morrison, John D.
core   +1 more source

Andrew Melville, sacred chronology and world history: the Carmina Danielis 9 and the Antichristus [PDF]

, 2009
The accepted view of the ecclesiastical reformer Andrew Melville (1545–1622) as the dynamic leader of the Presbyterian movement in Jacobean Scotland has been severely eroded in recent years, with particular criticism of the actual importance of his ...
Backus, Ball Bryan W., Bibliander, Burrell S. A., Durkan James, Firth Katharine R., Haag Emile, Kirk Durkan, Kirk Durkan, Lynch Michael, McGinnis Williamson, McGinnis Williamson, Most, Reid Steven John, Steven John Reid, Trinity College   +15 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source