Results 71 to 80 of about 263,686 (317)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
The Biais-Martimort-Rochet equilibrium with direct mechanisms [PDF]
In this note we show that the equilibrium characterized by Biais, Martimort and Rochet (Econometrica, 2000) could have been characterized by direct mechanisms even if the Revelation Principle does not apply in their setting. The use of more sophisticated
Gwenaël Piaser
core +3 more sources
A note on revelation principle from an energy perspective [PDF]
arXiv, 2010 The revelation principle has been known in the economics society for decades. In this paper, I will investigate it from an energy perspective, i.e., considering the energy consumed by agents and the designer in participating a mechanism. The main result is that when the strategies of agents are actions rather than messages, an additional energy ...
arxiv
Molecular Oncology, EarlyView.Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns +4 more
wiley +1 more source
Acta Theologica, 2004 Widely differing views on ways leading to true knowledge of God is at present characteristic of discussions in the sphere of religion. Although Calvin worked in a completely different scene, he has laid down certain principles based on his ...
P. C. Potgieter
doaj +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
First principles study of Sc, Ti and V doped Na$_n$(n =4, 5, 6) clusters: Enhanced magnetic moments [PDF]
, 2007 Theoretical studies on the geometry, electronic structure and spin multiplicity of Sc, Ti and V doped Na$_n$ (n = 4, 5, 6) clusters have been carried out within a gradient corrected density functional approach. Two complementary approaches including all-electron calculations on free clusters, and supercell calculations using planewave pseudopotential ...
arxiv +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Al-Mufid on the Scope of Inerrancy of the Prophets and Its Inconsistency with Their Knowledge [PDF]
پژوهشنامه فلسفه دین, 2019 Along with other Islamic theologians and philosophers, al-Shaykh al-Mufid believes in the inerrancy of prophets as far as it is related to the claim of prophethood, as well as reception and presentation of revelation and contends that they cannot commit ...
Malik Abdiyankordkandi +1 more
doaj +1 more source