Results 41 to 50 of about 824,283 (335)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Investment Returns for Preemergence Herbicide Use in No-till Pumpkin
HortScience, 2022 Preemergence (PRE) herbicides are an important part of the overall weed management plan in no-till (NT) pumpkin (Cucurbita pepo) production. A field evaluation was conducted in an NT production system using PRE herbicides labeled for pumpkins to ...
S. Alan Walters, Bryan G. Young
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Analysis of organizing sales activity in JSC «Nizhnekamsk bakery»
Путеводитель предпринимателя, 2020 This article presents the main indexes of the enterprise and the analysis of sales activity venture.
doaj
Revenue cycle management [PDF]
Journal of Vascular Surgery, 2009 With the widening gap between overhead expenses and reimbursement, management of the revenue cycle is a critical part of a successful vascular surgery practice. It is important to review the data on all the components of the revenue cycle: payer contracting, appointment scheduling, preregistration, registration process, coding and capturing charges ...
Manley, Ray, Satiani, Bhagwan
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
IMPACT OF SUBSIDIES ON THE FINANCIAL POSITION OF LOCAL GOVERNMENT BUDGETARY ESTABLISHMENTS IN POLAND
Polityki Europejskie, Finanse i Marketing, 2020 The article presents an assessment of the impact of subsidies received from the budget of a local government unit on the financial situation of local government budgetary establishments in Poland.
Piotr Sołtyk
doaj
Revenue equivalence revisited [PDF]
Games and Economic Behavior, 2008 The conventional wisdom in the auction design literature is that first price sealed bid auctions tend to make more money while ascending auctions tend to be more efficient. We re-examine these issues in an environment in which bidders are allowed to endogenously choose in which auction format to participate. Our findings are that more bidders choose to
Ivanova-Stenzel, Radosveta +1 more
openaire +2 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source