Results 141 to 150 of about 7,499 (273)

Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks. [PDF]

open access: yesNeurosci Bull, 2023
Li XW   +7 more
europepmc   +1 more source

Memimpedance‐Based Biomolecular Device for Adaptive Physical Reservoir Computing

open access: yesAdvanced Intelligent Systems, EarlyView.
By integrating fast‐switching ion‐channel‐based memristive and slow‐switching biomembrane‐based memcapacitive nodes within droplet interface bilayers, this hybrid memimpedance reservoir overcomes the memory‐nonlinearity trade‐off and extends temporal adaptability.
Ahmed S. Mohamed   +3 more
wiley   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

open access: yesAngewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij   +8 more
wiley   +2 more sources

Haptic Perception via the Dynamics of a Flexible Body Inspired by an Ostrich's Neck

open access: yesAdvanced Intelligent Systems, EarlyView.
Inspired by avian anatomy, this study uses a flexible robotic neck to investigate haptic perception driven by musculoskeletal dynamics. By applying physical reservoir computing, the robot encodes external force interactions into its body dynamics, allowing effective object classification.
Kazashi Nakano   +3 more
wiley   +1 more source

Efficient Synthesis of Chemically Recyclable Polyamides via Substituent Effects‐Enabled Mechanistic Pathway

open access: yesAngewandte Chemie, EarlyView.
The joint presence of ketone and diester functionalities in dimethyl acetone‐1,3‐dicarboxylate enhances its reactivity toward amines compared to the individual reactivity of each group, due to substituent effects. This increased reactivity enables the efficient synthesis of polyamides under mild conditions, and the resulting polymers are chemically ...
Youwei Ma   +6 more
wiley   +2 more sources

Real‐Time and Rapid Dynamic Missile Identification Utilizing a TiOx Memristor Array

open access: yesAdvanced Intelligent Systems, EarlyView.
Real‐time missile target identification is demonstrated using an artificial intelligence model based on step‐weighted long–short‐term memory networks and a TiOx memristor array. The approach classifies five projectile types with enhanced early‐stage prediction through data augmentation and custom training strategies. Achieving 94.4% accuracy, the model
Mingyu Kim, Gwanyeong Park, Gunuk Wang
wiley   +1 more source

The Intersection of HIV and Migration: Conceptualising Quality of Life Among Asian‐Born Men Who Have Sex With Men Living With HIV in Australia

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT This qualitative study aimed to understand how migration experiences shape wellbeing and quality of life (QoL) for Asian‐born men who have sex with men (MSM) who are living with HIV in Australia, and to identify relevant support needs. Drawing from intersectionality theory, this paper reports findings from semi‐structured interviews with Asian‐
Thomas Norman   +9 more
wiley   +1 more source

Co‐Opting MBNL‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy

open access: yesAnnals of Neurology, EarlyView.
Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell   +3 more
wiley   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

open access: yesAnnals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko   +9 more
wiley   +1 more source

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