Results 41 to 50 of about 777,330 (303)
The Astrophysical Journal, 2023 We present the first results from a 100-day Swift, NICER, and ground-based X-ray–UV–optical reverberation mapping campaign of the Narrow-line Seyfert 1 Mrk 335, when it was in an unprecedented low X-ray flux state.
Erin Kara +39 more
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Archives of Acoustics, 2021 Microphone array with minimum variance (MVDR) beamformer is a commonly used method for ambient noise suppression. Unfortunately, the performance of the MVDR beamformer is poor in a real reverberant room due to multipath wave propagation. To overcome this
Zoran ŠARIĆ +4 more
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EURASIP Journal on Advances in Signal Processing, 2022 This paper proposes a novel approach for improving the speech of a single speaker in noisy reverberant environments. The proposed approach is based on using a beamformer with a large number of virtual microphones with the suggested arrangement on an open
Mohammad Ebrahim Sadeghi +2 more
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Channel and temporal-frequency attention UNet for monaural speech enhancement
EURASIP Journal on Audio, Speech, and Music Processing, 2023 The presence of noise and reverberation significantly impedes speech clarity and intelligibility. To mitigate these effects, numerous deep learning-based network models have been proposed for speech enhancement tasks aimed at improving speech quality. In
Shiyun Xu, Zehua Zhang, Mingjiang Wang
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
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Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
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Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
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Journal of Algorithms & Computational Technology, 2009 In shallow water areas, to enhance underwater targets detection performance improve computation efficiency of active sonar, a computationally efficient adaptive beamformer (spatial filter) based on inverse QR (IQR) and recursive least-squares (RLS) is ...
Q. Wang, X. Pan
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