Results 121 to 130 of about 494,147 (304)

Development and Evaluation of Content Validity and Acceptance of a Multidomain Intervention Module for Reversal of Cognitive Frailty Among Older Adults

Clinical Interventions in Aging
Norhayati Mustafa Khalid,1 Pavapriya Ponvel,1 Azianah Mohamad Ibrahim,1 A’isyah Mohd Safien,1 Nurul Hidayah Md Fadzil,1 Devinder Kaur Ajit Singh,1 Arimi Fitri Mat Ludin,1 Norhayati Ibrahim,1 Ponnusamy Subramaniam,1 Hasnah Haron,1 Roslee Rajikan,1 Divya ...
Mustafa Khalid N, Ponvel P, Ibrahim AM, Mohd Safien A, Md Fadzil NH, Singh DKA, Mat Ludin AF, Ibrahim N, Subramaniam P, Haron H, Rajikan R, Vanoh D, Shahar S   +12 more
doaj  

“Let my liver rather heat with wine” - a review of hepatic fibrosis pathophysiology and emerging therapeutics

Hepatic Medicine: Evidence and Research, 2019
Carlos G Moscoso,1 Clifford J Steer1,21Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition; 2Department of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, MN 55455, USACorrespondence:
Moscoso CG, Steer CJ
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pseudowords’ reversal.

, 2015
Mean trajectories (panel A) and Euclidean based x-y acceleration profile (panel B) for trials marked as having a reversal or no reversal.
Laura Barca (324939), Giovanni Pezzulo (324940)   +1 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Reverse Training to Nurse the Reversal Curse

CoRR
Large language models (LLMs) have a surprising failure: when trained on "A has a feature B", they do not generalize to "B is a feature of A", which is termed the Reversal Curse. Even when training with trillions of tokens this issue still appears due to Zipf's law - hence even if we train on the entire internet.
Olga Golovneva, Zeyuan Allen-Zhu, Jason Weston, Sainbayar Sukhbaatar   +3 more
openaire   +3 more sources

‘Picking People to Hate’: Reversible reversals in stand-up comedy

Suomen Antropologi, 2017
Generally speaking, ritual reversals mean switching to the opposite of what is considered ‘the normal order’. Such reversals can occur, for example, in terms of social hierarchies in rites of passage, in action in carnival, or in the framing of action as
Marianna Keisalo
doaj  

Le rôle du langage ordinaire dans la subversion du droit, un défi pour l’épistémologie juridique : analyse de processus de renversement et de resignification du droit du mariage (1960-2013)

Criminocorpus
This article explains the mechanisms by which ordinary language subverts positive law in a case study devoted to marriage law between the 1960s and 2013.
Elena Mascarenhas
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source