Results 201 to 210 of about 312,344 (268)

Postoperative pulmonary complications after neuromuscular blockade: what does the recent evidence demonstrate? [PDF]

J Thorac Dis
Maisat W, Yuki K.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Anticoagulation Stewardship Program in the DOAC Era. [PDF]

J Clin Med
Ng JX, Tan SC, Koh PL, Yap ES.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Curcumin derivatives with 1,5-diaryl-3-oxo-1,4-pentadiene: novel dual-function lead compounds showing anticancer and MDR reversal effects. [PDF]

RSC Adv
Wang Q, Zhang X, Yuan J, Ren Y, Yan H, Sun J.   +5 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor. [PDF]

Childs Nerv Syst
Rafaelian A, Won SY, Mueller L, Armbrust M, Weber KJ, Haas A, Reuter DA, Freiman TM, Gessler F, Spang C, Meyer-Bahlburg A, Hingst P, Classen CF, Dubinski D, Cardesa-Salzmann TM.   +14 more
europepmc   +1 more source

Desire for reversal after tubal sterilization in the United States, 2006-2023. [PDF]

F S Rep
Chiang AY, Gariepy AM, Leon-Martinez D, Treder KM, Schwarz EB.   +4 more
europepmc   +1 more source

Reversal, Risk, and Responsibility in the Era of Potent Opioids and Overdose. [PDF]

Anesthesiology
Rathmell JP, Kern SE.
europepmc   +1 more source