Results 141 to 150 of about 23,572,323 (347)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Reverse score and likelihood ratio tests [PDF]

, 1999
Two extensions of a parametric model are proposed, each one involving the score function of an alternative parametric model. We show that the encompassing hypothesis is equivalent to standard conditions on the score of each of the extended models.
Dhaene, Geert, Scaillet, Olivier
openaire   +4 more sources

Demonstration; Drawbar Test; Waterloo Boy

, 1956
Demonstration at the Tractor Test Lab. This Waterloo Boy's manufacturer was bought later by John Deere. "Waterloo Boy by John Deere on kerosene was the first tractor tested at the University of Nebraska in 1920." The Waterloo Boy tractor is shown on the ...
Nebraska Tractor Test Laboratory
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A study on Irrational Beliefs and Emotions Associated with the Sexual Desire of Infertile Women

Armaghane Danesh Bimonthly Journal, 2013
Background & aim: The main aim of this study was to determine the irrational beliefs and emotions associated with the sexual desire of infertile women in Shiraz.
N Honarparvaran, Z Qudery, M Taghva, Z Zandi ghashghaee   +3 more
doaj  

Monitoring the efficiency of reversal on anti-Xa direct oral anticoagulants using point-of-care viscoelastic testing

Thrombosis Journal
Bleeding events in patients receiving direct oral anticoagulation (DOAC) can be life-threatening even at therapeutic DOAC plasma concentrations, as anticoagulation impairs hemostasis and should therefore be identified immediately after hospital admission.
Lars Heubner, Oliver Grottke, Oliver Vicent, Peter Markus Spieth, Jan Beyer-Westendorf   +4 more
doaj   +1 more source

Effect of Distal Loop Stimulation with Ileostomy Effluent on Return of Bowel Function Post Ileostomy Reversal in Emergency Laparotomy Patients

Tropical Gastroenterology
Context: Postoperative ileus is the most common complication of ileostomy reversal. Aim: The aim is to evaluate the effect of reinfusion of proximal loop effluent into the distal loop of stoma in bowel function recovery in patients with ileostomy ...
Tiyasa Santra, Supreet Kaur, Sanjay Gupta, Iqbal Singh   +3 more
doaj   +1 more source

Tractor Testing; PTO Test; Jeep

, 1949
"Willys Jeep being tested at Nebraska Tractor Test Laboratory." Willys-Overland Motors Jeep CJ-3A Universal is shown inside the tractor test lab. After WWII, with many jeeps being surplus and a lack of tractors, the Jeep as well as the Dodge Power wagon ...
Nebraska Tractor Test Laboratory
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Process Practice for Reducing Width of Side Reversal of Hot Rolled Coil by Reentrant Casting of Slab

Teshugang, 2009
Effect of reentrant casting of slab on the side reversal ( both side roughness band) of hot rolled coil and the mold life is obtained by test of reentrant casting of 180 mm X 1 238 mm 0Cr18Ni9 stainless steel slab. Results show that as the cast slab side
尹德
doaj