Results 171 to 180 of about 23,572,323 (347)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Three-week ileostomy closure after colorectal surgery: a multicenter randomized trial of technical and postoperative outcomes. [PDF]

Tech Coloproctol
Debakey Y, Mostafa MS, Kilany A, Madkour A, Mohamed AR, El-Mikkawy A, Sheier SS, Hafez A, ElSabbagh O, Nofal A.   +9 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dopamine dynamics promote cooperative behavior not just the rewards accompanying cooperation. [PDF]

iScience
Chai K, Cai J, Zhuo Y, Da N, Wang W, Liu H, Yao D, Xia Y, Chen K, Li L.   +9 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial. [PDF]

Lasers Med Sci
Mohamed ZUH, Ahalya P, Vinay C, Ravigna P, Arany P, Uloopi KS.   +5 more
europepmc   +1 more source

Test Track; Maintenance

, 1970
Water wagon sprays the soil test area beside the concrete track. The disced ground alongside the track is sprayed with water. This is in preparation for some future special tests.
Nebraska Tractor Test Laboratory
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Is the International Normalized Ratio (INR) Enough? Reevaluating INR-Based Decision-Making for Four-Factor Prothrombin Complex Concentrate in Geriatric Warfarin-Associated Intracranial Hemorrhage: A Multicenter Cohort Study. [PDF]

Biomedicines
Dogan Y, Avci A, Guven R, Sogut O, Dogan S, Karamercan MA, Altınbilek E, Altug E, Avci BS, Az A, Eyupoglu G, Kural S, Alp O, Ozmen M, Guven O, Simsek Y, Aksay E, Urfalioglu AB, Tura PO, Yilmaz HK, Tunca S, Ilcin C, Bala ED, Guvercin M.   +23 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source