Results 51 to 60 of about 182,598 (263)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A Calculation Method and Application Research in Gas-Lift Reverse Circulation Bottom-Hole Pressure Based on Gas–Liquid Two-Phase Flow Theory

Fluids
Gas-lift reverse circulation drilling technology is one of the typical “bottom-hole negative pressure” drilling technologies. This technology can significantly reduce wellbore circulation pressure loss, alleviate the bottom-hole pressure holding effect ...
Pu Liu, Chuanhua Ge, Ruiqi Zhang, Ruifeng Tan, Shanquan Fan   +4 more
doaj   +1 more source

Vortex evolution near the Coanda surface of a circulation control airfoil with pulsed actuation

AIP Advances, 2022
A special vortex evolution process was found near the Coanda surface for circulation control airfoil with pulsed actuation. For the jet-on process, two successive shedding vortices from the lower lip edge and the separation vortex on the Coanda surface ...
Quanbing Sun, Zhiwei Shi, Weilin Zhang, Sinuo Chen, Jie Chen   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Air-Lifting Reverse-Circulation Drilling in Deep Geothermal Wells and the Effect of Dual-Wall Drill Pipe Depth Down the Hole

Energies
Geothermal energy is a renewable energy source that is rich in reserves, widely distributed, stable and reliable. The development of geothermal energy needs to be carried out by drilling wells to exploit the underground thermal fluid, and air-lift ...
Hongyu Ye, Ziwei Lai, Longjun Tian, Renjie Zhang, Bin Liu, Xiuhua Zheng   +5 more
doaj   +1 more source

Dynamics of Reversed Urban Breeze Circulation

Journal of the Atmospheric Sciences, 2017
Abstract The urban breeze circulation (UBC) is a thermally forced mesoscale circulation that is characterized by low-level inward flow toward the urban center, updrafts near the urban center, upper-level outward flows, and weak downdrafts outside the urban area.
Jaemyeong Mango Seo, Gantuya Ganbat, Jong-Jin Baik   +2 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Reversibility of the Effects of Aliskiren in the Renal Versus Systemic Circulation [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Background and objectives Renal hemodynamic effects of inhibitors of the renin-angiotensin system can increase the risk of acute kidney injury under certain conditions. The BP-lowering effects of the renin inhibitor aliskiren are sustained 3–4 weeks after withdrawal.
Markus P, Schneider, Rolf, Janka, Thomas, Ziegler, Ulrike, Raff, Martin, Ritt, Christian, Ott, Roland, Veelken, Michael, Uder, Roland E, Schmieder   +8 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The Development of Multifunction Wellbore Cleaning Tool

Shiyou jixie, 2016
The wellbore cleaning tool of foreign service company features single function, no specific collection schemes for different debris and poor fishing performance.
Yu Pengwei, Zuo Qichuan, Zhu He, Wang Degui, Xu Chunyuan, Ma Dong   +5 more
doaj