Results 91 to 100 of about 11,383,460 (294)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Expertise Reversal Effect

open access: yes, 2009
Cognitive studies of expertise that were reviewed in Chapter I indicated that prior knowledge is the most important 1earner characteristic that influences learning processes. Recently, it has been established that learning procedures and techniques that are beneficial for learners with low levels of prior knowledge may become relatively inefficient for
John Sweller, Paul Ayres, Slava Kalyuga
openaire   +3 more sources

Language Transfer: A Dead Issue? - Reflecting on ‘Reverse Transfer’ and ‘Multicompetence’

open access: yesJournal of Child Language Acquisition and Development, 2021
There has been extensive research into how L1 affects L2, commonly known as ‘negative influence’, but a lot less about the opposite direction, commonly known as ‘Reverse or Backward’ transfer.
Hosni Mostafa El-dali
doaj  

Reverse effect of Semaphorin-3F on rituximab resistance in diffuse large B-cell lymphoma via the Hippo pathway. [PDF]

open access: yesChin Med J (Engl), 2023
Li Q   +14 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Investigating Strategies to Support Reverse-Engineering of Interactive Systems [PDF]

open access: yes, 2013
Most software applications today provide a graphical user interface (GUI), which facilitates the use of the software by offering graphical and visual elements to the users.
Alsharif, Aman
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Test system creation for analysis of template switching effect during a reverse transcription in vitro

open access: yesТонкие химические технологии, 2011
We investigated an in vitro system for the analysis of template switching effect of RNA-dependent DNA-polymerase during reverse transcription reaction. An RT-PCR-based approach was realized. An RNA sample was used as a template. The RNA contains a region
A. Y. Komkov   +2 more
doaj  

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