Results 321 to 330 of about 2,173,029 (360)

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu   +5 more
wiley   +1 more source

Rescuing Newcastle disease virus with tag for screening viral-host interacting proteins based on highly efficient reverse genetics. [PDF]

open access: yesFront Vet Sci
Wang R   +12 more
europepmc   +1 more source
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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins.

Journal of Visualized Experiments, 2020
Rotaviruses are a large and evolving population of segmented double-stranded RNA viruses that cause severe gastroenteritis in the young of many mammalian and avian host species, including humans.
Asha A. Philip   +3 more
semanticscholar   +1 more source

Forward in Reverse: How Reverse Genetics Complements Chemical Genetics

Pharmacogenomics, 2005
Pharmaceutical discovery has a renewed interest in physiological screening, while chemical genomics initiatives will soon provide a large amount of cellular assay data. However, there is no single robust approach to connect active compounds with their targets, limiting their experimental and therapeutic use.
openaire   +2 more sources

Reverse genetics

1999
Abstract The nematode Caenorhabditis elegans has about 19000 genes. Approximately 2000 of these have been identified in forward genetic screens for animals with mutant phenotypes. The generation and analysis of such mutants has been the key to the success of the C. elegans model because the in vivo function of a gene can be inferred from
openaire   +1 more source

Reverse Genetics of Picornaviruses

1999
Publisher Summary This chapter focuses on the reverse genetics of picornaviruses. The family Picornaviridae includes a large number of human and animal pathogens, all related by the possession of a small, nonenveloped, icosahedral particle and a single-stranded, positive-sense, RNA genome.
openaire   +2 more sources

Reverse Genetics and Cystic Fibrosis

American Journal of Respiratory Cell and Molecular Biology, 1990
The protein responsible for cystic fibrosis has been identified using an approach called "reverse" genetics. This approach relies on the chromosomal map position to direct the search for a disease gene, several novel cloning strategies to isolate the gene, and the gene's sequence to define the abnormal protein.
M C, Iannuzzi, F S, Collins
openaire   +2 more sources

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