Results 31 to 40 of about 1,683,204 (225)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Inter-American Development Bank Annual Report 2018: Financial Statements
, 2019 This report is the second of two volumes which together constitute the Inter-American Development Bank\u27s 2018 Annual Report. This report contains the management\u27s discussion and analysis of the Bank\u27s ordinary capital and financial ...
Inter-American Development Bank
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Inter-American Development Bank Cultural Center Information Bulletin: No. 75
, 2004 Presents projects approved to receive financial support during 2004 of Cultural Development in the Field Program, Inter-American Development Bank Cultural ...
Inter-American Development Bank
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A Partnership with Purpose: The Inter-American Development Bank and PepsiCo [PDF]
, 2016 This publication tells the story of the collaboration between the Inter-American Development Bank, PepsiCo, and the PepsiCo Foundation. At a February 2011 ceremony in Mexico City, a five-year Memorandum of Understanding was signed by IDB President Luis ...
Inter-American Development Bank
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Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Inter-American Development Bank Cultural Center Information Bulletin: No. 123
, 2011 This bulletin announces the opening of the exhibition "New Visions: A Selection of the Latest Acquisitions from the IDB Art Collection, 2008-2011". This exhibition is part of the 19th anniversary celebrations of the Inter-American Development Bank (IDB ...
Inter-American Development Bank
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Independent Advisory Group on Sustainability: Final Report to the Inter-American Development Bank [PDF]
, 2011 The Independent Advisory Group on Sustainability (IAG) is pleased to submit this final report to the Board of Executive Directors and Management of the Inter-American Development Bank (IDB).
Inter-American Development Bank
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Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source