Results 51 to 60 of about 33,228 (257)
آموزش مهندسی ایران, 2015 3D Spatial ability is an important and vital ability for engineering disciplines in the fields such as designing, modeling, reverse engineering, production and manufacturing and etc.
Mahdi Motaghipour
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
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Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Entropy, 2021 Representation and abstraction are two of the fundamental concepts of computer science. Together they enable “high-level” programming: without abstraction programming would be tied to machine code; without a machine representation, it would be a pure ...
Raymond Turner
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Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
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Notices of the American Mathematical Society, 2018 Reverse mathematics is a new field that seeks to find the axioms needed to prove given theorems. Reverse mathematics began as a technical field of mathematical logic, but its main ideas have precedents in the ancient field of geometry and the early twentieth-century field of set theory. This book offers a historical and representative view, emphasizing
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Coloring the rationals in reverse mathematics [PDF]
Computability, 2016 Ramsey’s theorem for pairs asserts that every 2-coloring of the pairs of integers has an infinite monochromatic subset. In this paper, we study a strengthening of Ramsey’s theorem for pairs due to Erdős and Rado, which states that every 2-coloring of the pairs of rationals has either an infinite 0-homogeneous set or a 1-homogeneous set of order type η,
Emanuele Frittaion, Ludovic Patey
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