Results 51 to 60 of about 4,479,330 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Application and Kinematics Analysis of Noncircular Gear Swinging Guide Bar mechanism

Jixie chuandong, 2017
In order to satisfy the specific engineering application requirements of swinging guide bar mechanism,the swing guide bar mechanism can be driven by motor output one-way variable motion under the conditions of each bar length is determined,the output ...
Cai Jun
doaj  

An exploratory study of software reverse engineering in a security context

, 2011
Illegal cyberspace activities are increasing rapidly and many software engineers are using reverse engineering methods to respond to attacks. The security-sensitive nature of these tasks, such as the understanding of malware or the decryption of ...
SALOIS, Martin, Christoph Treude, Treude, C., Fernando Figueira Filho, Salois, M., Filho, F., Storey, M., TREUDE, Christoph, STOREY, Margaret-Anne, Martin Salois, Margaret-Anne Storey, FIGUEIRA FILHO, Fernando   +11 more
core   +1 more source

Motion sickness, stress and the endocannabinoid system [PDF]

, 2010
A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel.
Kreth Simone, Feuerecker, Matthias, Matthias Feuerecker, Ines Kaufmann, Kaufmann, Ines, Kreth, Simone, Thieme, Detlef, Thieme Detlef, Choukèr Alexander, Schelling Gustav, Feuerecker Matthias, Michael Vogeser, Kaufmann Ines, Vogeser Michael, Manfred Thiel, Schelling, Gustav, Vogeser, Michael, Choukèr, Alexander, Detlef Thieme, Thiel, Manfred, Gustav Schelling, Alexander Choukèr, Daniela Hauer, Thiel Manfred, Hauer, Daniela, Simone Kreth, Hauer Daniela   +26 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reverse Design of Conjugate Cam Mechanism based on Polynomial Fitting Method

Jixie chuandong, 2015
A method of reverse design of conjugate cam is introduced. By using Pro / E with the contour surface data of CAM,the 3- D model is built and kinematics simulation analysis is carried out,the displacement,velocity and acceleration curves of the following ...
Zhang Shuanglin, Ge Zhenghao, Zhang Xingyu, Li Chengping   +3 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Internal structure of the fly elementary motion detector [PDF]

, 2012
Flies use visual motion information for flight control, stabilization and object tracking. However, information about local motion such as direction and velocity is not explicitly represented at the level of the retina but must be computed by subsequent ...
Eichner, Hubert
core   +1 more source

Inversion of Side Scan Sonar Motion and Posture in Seabed Geomorphology

Polish Maritime Research, 2017
Side scan sonar measurement platform, affected by underwater environment and its own motion precision, inevitably has posture and motion disturbance, which greatly affects accuracy of geomorphic image formation.
Tao Weiliang, Liu Yan, Hu Wenbin
doaj   +1 more source