Results 61 to 70 of about 3,860 (212)

C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression.

PLoS Genetics, 2007
Chromosome inheritance during sexual reproduction relies on deliberate induction of double-strand DNA breaks (DSBs) and repair of a subset of these breaks as interhomolog crossovers (COs).
Michiko Hayashi, Gregory M Chin, Anne M Villeneuve   +2 more
doaj   +1 more source

Fontes protéicas suplementadas com aminoácidos e minerais para a tilápia do Nilo durante a reversão sexual Protein sources supplemented with amino acids and minerals to Nile tilapia during sex reversal phase

Revista Brasileira de Zootecnia, 2005
Objetivou-se, no presente experimento, comparar o efeito da origem da fonte protéica e da suplementação com lisina e metionina ou cálcio e fósforo para a tilápia do Nilo (Oreochromis niloticus), durante a reversão sexual.
Fábio Meurer, Carmino Hayashi, Wilson Rogério Boscolo, Christiano Rodrigues Schamber, Robie Allan Bombardelli   +4 more
doaj   +1 more source

Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival

International Journal of Cancer, EarlyView.
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li, Elaheh Zarean, Danmeng Lily Li, Yiyue Zhu, Shuai Li, Enes Makalic, Catriona McLean, Graham G. Giles, Roger L. Milne, Melissa C. Southey, Pierre‐Antoine Dugué   +10 more
wiley   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Characterization and mapping of an informational suppressor in Aspergillus nidulans

Biological Research, 2000
The present work was undertaken to characterize a suppressor gene present in a mutant strain of A. nidulans obtained with NTG (N-Methyl-N'-Nitro-N-Nitrosoguanidine).
MELISSA GRACITE DE MELO FRANZONI, MARIALBA AVEZUM ALVES DE CASTRO-PRADO   +1 more
doaj  

Impact of cystic fibrosis transmembrane conductance regulator modulator therapies on liver stiffness and liver enzymes: An observational perspective single‐center cohort study

JPGN Reports, EarlyView.
Abstract Objectives The efficacy of cystic fibrosis transmembrane conductance regulator (CFTR)‐modulator therapies in preventing or ameliorating cystic fibrosis liver disease (CFLD) by correcting CFTR in cholangiocytes is not well‐documented. This study aimed to assess liver function during CFTR‐modulators.
Laura Giugliano, Elisabetta Augustoni, Antonio Pizzol, Anna Opramolla, Cristina Chiadò, Anna Zagaria, Irene Esposito, Giulia Roberto, Alice Ponte, Andrea Evangelista, Paola Quarello, Michele Pinon, Pier Luigi Calvo   +12 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

SISTEMAS DE DETERMINACIÓN DE SEXO Y SU EVOLUCIÓN: Caso mamíferos

Acta Biológica Colombiana, 2012
RESUMEN Los sistemas de determinación de sexo son extremadamente variados, razón por la cual, han constituido un campo de constante investigación. Comprender como se determina el desarrollo gonadal y más aun dilucidar los procesos allí implicados, ha ...
Fredy Alexander Colorado Garzón, Nubia Estela Matta Camacho   +1 more
doaj  

Open‐land‐derived agroforestry and effects of abandonment of management of the main crop on ecosystem services and woody plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
Tropical forests are rapidly declining. One promising strategy to reverse the loss of tropical forest is the establishment of agroforestry on open land. We combined interviews with biodiversity surveys to learn general lessons from success and nonsuccess stories of the establishment of open‐land‐derived coffee agroforests in one of the world's ...
Lucas M. Fonzaghi, Kristoffer Hylander, Thiago S. de Melo, Ayco J. M. Tack   +3 more
wiley   +1 more source