Results 41 to 50 of about 96,351 (269)
Ring-Opening Reaction of 1-Phospha-2-Azanorbornenes via P-N Bond Cleavage and Reversibility Studies
Molecules, 2023 The reactive P-N bond in 1-phospha-2-azanorbornenes is readily cleaved by simple alcohols to afford P-chiral 2,3-dihydrophosphole derivatives as a racemic mixture.
Kyzgaldak Ramazanova +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
From Reversible Semantics to Reversible Debugging [PDF]
, 2018 This paper presents a line of research in reversible computing for concurrent systems. This line of research started in 2004 with the definition of the first reversible extensions for concurrent process calculi such as CCS, and is currently heading to the production of practical reversible debuggers for concurrent languages such as Erlang.
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Investigation of Reversibility of Asphaltene Precipitation and Deposition for an Iranian Crude Oil [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2006 In this work, the precipitation and re-dissolution of asphaltenes were studied for an Iranian relatively heavy crude oil. A series of experiments were designed and carried out to quantitatively examine the reversibility of asphaltenes precipitation upon ...
Siavash Ashoori +3 more
doaj
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Substitution-Induced Mechanistic Switching in SNAr-Warheads for Cysteine Proteases
MoleculesThe aim of this study was to investigate the transition from non-covalent reversible over covalent reversible to covalent irreversible inhibition of cysteine proteases by making delicate structural changes to the warhead scaffold. To this end, dipeptidic
Collin Zimmer +8 more
doaj +1 more source
Reversible Computation vs. Reversibility in Petri Nets [PDF]
Science of Computer Programming, 2016 Abstract Petri nets are a general formal model of concurrent systems which supports both action-based and state-based modelling and reasoning. One of important behavioural properties investigated in the context of Petri nets has been reversibility, understood as the possibility of returning to the initial marking from any reachable net marking.
Kamila Barylska +3 more
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source