Results 161 to 170 of about 840,630 (239)

Concept analysis of digital dementia

Huli yanjiu
ObjectiveTo analyze the concept of digital dementia,and to provide reference for related research and clinical practice.MethodsA systematic search and analysis of literature related to digital dementia in Chinese and English databases was conducted by ...
CAO Yanke, TAN Tongyu, XU Yuhan, ZHANG Zhenzhen, LI Yan, SHEN Xiangdan   +5 more
doaj  

Clinical Spectrum of Reversible Cerebral Vasoconstriction Syndrome With and Without Angiographic Vasoconstriction: A Retrospective Study of 84 Hospitalized Patients. [PDF]

Brain Behav
Takeuchi K, Kikui S, Matsumoto Y, Murakata K, Sugiyama H, Ota K, Danno D, Kashiwaya Y, Takeshima T.   +8 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Circadian-Inspired Hydrogel Moisture Electricity Generation. [PDF]

Adv Sci (Weinh)
Li Z, Ahemaitijiang D, Yang H, Zhao X, Pan M, Wan J, Zhu P, Shou D.   +7 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Interpenetrating Dual Epoxy Networks with Reversible Covalent Bonds: Shape-Constant Self-Healing Electrically Insulating Materials. [PDF]

ACS Appl Polym Mater
Strachota B, Strachota A, Kadlec P, Polanský R, Batakliev T.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Reversible, Chemically Gated FRET via Ligand-Activated Acceptors. [PDF]

Adv Sci (Weinh)
Singh N, Nayak SR, Mohanty SK, Hanumantharaju A, Shaju A, Jose M, Penmatsa A, Nair D.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Accelerated immunostaining of thick biological tissues using bidirectional electric fields with reversible deformation. [PDF]

Biomed Opt Express
Zhou Z, Xiao X, Du L, Zhu J, Du Z, Zheng Y, Si K, Gong W.   +7 more
europepmc   +1 more source