Results 101 to 110 of about 1,859,804 (254)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Reversible watermarking scheme with image-independent embedding capacity [PDF]

Permanent distortion is one of the main drawbacks of all the irreversible watermarking schemes. Attempts to recover the original signal after the signal passing the authentication process are being made starting just a few years ago. Some common problems,
Li, Chang-Tsun
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

On Double Cyclic Codes and Applications to DNA Codes

Mathematics
In this paper, we investigate the structure of double cyclic codes of length (α,β) over R=F4+ϱF4,ϱ2=0 and give a minimal spanning set of double cyclic codes. Moreover, we extend this study to construct DNA codes from R-double cyclic codes.
Amal S. Alali, Mohd Anwar, Muzibur Rahman Mozumder   +2 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Experimental Investigation on a Reversible Heat Pump for a Passenger Car [PDF]

, 2012
This paper summarizes the first results of a research project dealing with the development of a reversible heat pump for a passenger car. Heat pump systems appear to be a more efficient alternative to electrical resistance heaters for the purpose of ...
Cuevas, Cristian, Declaye, Sébastien, Lemort, Vincent   +2 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Reversible implementation of a disrete linear transformation

, 2010
Discrete linear transformations form important steps in processing information. Many such transformations are injective and therefore are prime candidates for a physically reversible implementation into hardware. We present here the first steps towards a
De Vos, AlexisTW06801000317026F3AF1814-F0ED-11E1-A9DE-61C894A0A6B4, Burignat, StéphaneTW06802000712984265C4084-F0EE-11E1-A9DE-61C894A0A6B4, Thomsen, Michael, Drechsler, Rolfeditor   +3 more
core  

Robust and compact reversible logic gate for low-power and high-performance computing

Scientific Reports
Reversible logic is a design paradigm suitable to energy-efficient digital systems and has lately received recognition as a viable option for designing sophisticated digital applications. It possesses the capacity to revolutionize progress in quantum and
Anju Rajput, Renu Kumawat, Avireni Srinivasulu, Jyoti Sharma   +3 more
doaj   +1 more source