Results 51 to 60 of about 246,403 (284)
Reverse Transcribing the Code for Chromosome Stability [PDF]
Molecular Cell, 2009 The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.
Artandi, Steven E. +1 more
openaire +2 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
From a reversible code to the quantum one: R-matrix
EPJ Web of Conferences, 2018 This research has been carried out in collaboration with D.Melnikov, A.Mironov, A.Morozov and An.Morozov. We study the relation between quantum programming and knot theory.
Mironov S.
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Construction of reversible MDS codes in the Rosenbloom-Tsfasman metric
AIMS MathematicsMaximum distance separable (MDS) codes are a type of error-correcting codes that aim to optimize the shortest possible distance between codewords.
Bodigiri Sai Gopinadh, Venkatrajam Marka
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A Matrix-Theoretic Approach to the Construction of Reversible DNA Codes Over
IEEE AccessLet $n,k$ , and t be the positive integers. The primary aim of this paper is to introduce a new approach for the construction of reversible and reversible DNA codes using the concept of double-reflected matrices of any matrices over a commutative ring ...
Elif Segah Oztas +5 more
doaj +1 more source
LDPC and SHA based iris recognition for image authentication
Egyptian Informatics Journal, 2012 We introduce a novel way to authenticate an image using Low Density Parity Check (LDPC) and Secure Hash Algorithm (SHA) based iris recognition method with reversible watermarking scheme, which is based on Integer Wavelet Transform (IWT) and threshold ...
K. Seetharaman, R. Ragupathy
doaj +1 more source