Results 201 to 210 of about 23,915,049 (293)

Gate Metal‐Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems

open access: yesAdvanced Science, EarlyView.
Intrinsically stretchable OECTs enable bifunctional operations via gate engineering. Polarizable Ag/AgCl gates provide volatile sensing, while Au gates enable non‐volatile memory. The SEBS‐blended channel maintains performance under strain, supporting reliable signal transduction.
Jiyong Yoon   +8 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

open access: yesAdvanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang   +21 more
wiley   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

A Survey on Reversible Data Hiding

open access: yesInternational Journal of Science and Research (IJSR), 2016
openaire   +1 more source

Mechanically Reprogrammed Coaxial Fibers for Multiphysics Transduction and Human‐Machine Interfaces

open access: yesAdvanced Science, EarlyView.
A continuously wet‐spun coaxial fiber is developed to combine stretchable conductivity, resistive sensing, and self‐powered triboelectric sensing in a single architecture. A mechanically reprogrammed dual‐network sheath stabilizes large deformation and improves signal reliability. These fibers can be woven into textile interfaces for multichannel touch
Xinyi Cao   +6 more
wiley   +1 more source

Pressure‐Tuned Superconducting Dome and Persistent Charge‐Density‐Wave Order in NdSeTe2

open access: yesAdvanced Science, EarlyView.
NdSeTe2 exhibits an unusual pressure‐tuned phase diagram in which charge‐density‐wave order does not disappear at optimal superconductivity. Instead, Raman spectroscopy reveals a transformation from long‐range to short‐range correlations that remain invisible to resistivity and persist across the entire superconducting dome.
Shuyang Wang   +6 more
wiley   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang   +5 more
wiley   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

open access: yesAdvanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy