Results 61 to 70 of about 604,680 (287)
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Porphene and porphite as porphyrin analogs of graphene and graphite
Two-dimensional materials have unusual properties and promise applications in nanoelectronics, spintronics, photonics, (electro)catalysis, separations, and elsewhere. Most are inorganic and their properties are difficult to tune.
Thomas F. Magnera +9 more
doaj +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Let R be a ring, (M, ≤) a strictly ordered monoid and ω : M → <em>End</em>(R) a monoid homomorphism. The skew generalized power series ring R[[M; ω]] is a compact generalization of (skew) polynomial rings, (skew) power series rings, (skew ...
R. K. Sharma, Amit B. Singh
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Smarandache Non-Associative (SNA-) rings [PDF]
In this paper we introduce the concept of Smarandache non-associative rings, which we shortly denote as SNA-rings as derived from the general definition of a Smarandache Structure (i.e., a set A embedded with a week structure W such that a proper subset ...
Vasantha Kandasamy, W.B.
core +1 more source
One-pot synthesis of block-copolyrotaxanes through controlled rotaxa-polymerization
The aqueous reversible addition fragmentation chain-transfer (RAFT) copolymerization of isoprene and bulky comonomers, an acrylate and an acrylamide in the presence of methylated β-cyclodextrin was employed for the first time to synthesize block ...
Jessica Hilschmann +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
An Introduction to i-Commutative Rings
In this paper, we introduce a new class of rings, called i-commutative rings, by extending the concept of commutative-like rings using idempotent elements.
Muhammad Saad +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source

