Results 21 to 30 of about 60,706 (202)

The 'Humour' element in engineering lectures across cultures:An approach to pragmatic annotation [PDF]

open access: yes, 2016
Humour is one of the most difficult pragmatic devices for lecturers and students to engage with, and for researchers to identify systematically. Humour does not always travel well across cultures.
Alsop, Sian
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On MDS Negacyclic LCD Codes

open access: yes, 2018
Linear codes with complementary duals (LCD) have a great deal of significance amongst linear codes. Maximum distance separable (MDS) codes are also an important class of linear codes since they achieve the greatest error correcting and detecting ...
Koroglu, Mehmet E., Sarı, Mustafa
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Optimal Linear and Cyclic Locally Repairable Codes over Small Fields

open access: yes, 2015
We consider locally repairable codes over small fields and propose constructions of optimal cyclic and linear codes in terms of the dimension for a given distance and length.
Yaakobi, Eitan, Zeh, Alexander
core   +1 more source

Multimodal Data‐Driven Microstructure Characterization

open access: yesAdvanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang   +4 more
wiley   +1 more source

Selective and Precise Editing of Digital Polymers Through Parallel or Series Toehold‐Mediated Strand Displacement

open access: yesAdvanced Functional Materials, EarlyView.
A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski   +3 more
wiley   +1 more source

On privacy amplification, lossy compression, and their duality to channel coding

open access: yes, 2018
We examine the task of privacy amplification from information-theoretic and coding-theoretic points of view. In the former, we give a one-shot characterization of the optimal rate of privacy amplification against classical adversaries in terms of the ...
Renes, Joseph M.
core   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

open access: yesAdvanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska   +7 more
wiley   +1 more source

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