Results 101 to 110 of about 25,627,615 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Consideration of health inequity in systematic reviews and primary studies on risk factors for hearing loss

Cochrane Evidence Synthesis and Methods
Background Health inequities are systematic, avoidable, and unfair differences in health between populations or population subgroups. There is increased recognition of the need for systematic reviews (SRs) to address health inequities, including drawing ...
Simon Briscoe, Elizabeth Shaw, Michael Nunns, Hassanat Lawal, Noreen Orr, Jo Thompson Coon, Ruth Garside, G. J. Melendez‐Torres   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Editorial: Insights (January 2020)

Technology Innovation Management Review, 2020
Stoyan Tanev, Gregory Sandstrom
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Editorial: Artificial Intelligence and Innovation Management (December 2019)

Technology Innovation Management Review, 2019
Stoyan Tanev, Gregory Sandstrom
doaj   +1 more source

Editorial: Insights (July 2020)

Technology Innovation Management Review, 2020
Stoyan Tanev, Gregory Sandstrom
doaj   +1 more source

Reviewing reviewers [PDF]

British Journal of Psychiatry, 1990
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Editorial: Innovating in Times of Crisis (September 2020)

Technology Innovation Management Review, 2020
Stoyan Tanev, Gregory Sandstrom
doaj   +1 more source