Results 131 to 140 of about 35,471,630 (314)
Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica +10 morewiley +1 more sourceTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker +19 morewiley +1 more sourceReview of Particle Physics
Physical Review D, 1996 K. Nakamura, K. Hagiwara, K. Hikasa, H. Murayama, M. Tanabashi, T. Watari, C. Amsler, M. Antonelli, D. Asner, H. Baer, H. Band, R. Barnett, T. Basaglia, E. Bergren, J. Beringer, G. Bernardi, W. Bertl, H. Bichsel, O. Biebel, E. Blucher, S. Blusk, R. Cahn, M. Carena, A. Ceccucci, D. Chakraborty, Mu-Chun Chen, R. Chivukula, G. Cowan, O. Dahl, G. D’Ambrosio, T. Damour, D. Florian, A. Gouvea, T. DeGrand, G. Dissertori, B. Dobrescu, M. Doser, M. Drees, D. Edwards, S. Eidelman, J. Erler, V. Ezhela, W. Fetscher, B. Fields, B. Foster, T. Gaisser, L. Garren, H. Gerber, G. Gerbier, T. Gherghetta, G. Giudice, S. Golwala, M. Goodman, C. Grab, A. Gritsan, J. Grivaz, D. Groom, M. Grunewald, A. Gurtu, T. Gutsche, H. Haber, C. Hagmann, K. Hayes, M. Heffner, B. Heltsley, J. Hernández-Rey, A. Hocker, J. Holder, J. Huston, J. Jackson, K. Johnson, T. Junk, A. Karle, D. Karlen, B. Kayser, D. Kirkby, S. Klein, C. Kolda, R. Kowalewski, B. Krusche, Yu. V. Kuyanov, Y. Kwon, O. Lahav, P. Langacker, A. Liddle, Z. Ligeti, Chen Lin, T. Liss, L. Littenberg, K. S. Lugovsky, S. Lugovsky, J. Lys, H. Mahlke, T. Mannel, A. Manohar, W. Marciano, Alan D. Martin, A. Masoni, D. Milstead, R. Miquel, K. Mönig, M. Narain, P. Nason, S. Navas, P. Nevski, Y. Nir, K. Olive, L. Pape, C. Patrignani, J. Peacock, S. Petcov, A. Piepke, G. Punzi, A. Quadt, S. Raby, G. Raffelt, B. Ratcliff, P. Richardson, S. Roesler, S. Rolli, A. Romaniouk, L. Rosenberg, J. Rosner, C. Sachrajda, Y. Sakai, G. Salam, S. Sarkar, F. Sauli, O. Schneider, K. Scholberg, D. Scott, W. Seligman, M. Shaevitz, M. Silari, T. Sjöstrand, J. Smith, G. Smoot, S. Spanier, H. Spieler, A. Stahl, T. Stanev, S. Stone, T. Sumiyoshi, M. Syphers, J. Terning, M. Titov, N. P. Tkachenko, N. Tornqvist, D. Tovey, T. Trippe, G. Valencia, K. Bibber, G. Venanzoni, M. Vincter, P. Vogel, A. Vogt, W. Walkowiak, C. Walter, D. Ward, B. Webber, G. Weiglein, E. Weinberg, J. Wells, A. Wheeler, L. Wiencke, C. Wohl, L. Wolfenstein, J. Womersley, C. Woody, R. Workman, A. Yamamoto, W. Yao, O. Zenin, Jiayu Zhang, R. Zhu, P. Żyła, G. Harper, V. S. Lugovsky, P. Schaffner +178 moresemanticscholar +1 more sourceChemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more source
