Results 291 to 300 of about 27,119,175 (328)

A step-by-step guide for conducting an umbrella review. [PDF]

Trop Med Health
Abdellatif M, Dadam MN, Vu NT, Nam NH, Hoan NQ, Taoube Z, Tran P, Huy NT.   +7 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Gas Station Heroin: A Case Report of Tianeptine Use Disorder and a Literature Review. [PDF]

Cureus
Kandra K, Gajagowni R, Fernandez GA, Polechonski N, Blewett BP.   +4 more
europepmc   +1 more source

Reviews

, 1990
openaire   +15 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Role of health workers and representative health worker organisations in LMIC pharmaceutical policy: a scoping review protocol. [PDF]

BMJ Open
Eisenkraft Klein D, Noor MN, Eiwanger L, Linton J, Ellis U, Sriram V.   +5 more
europepmc   +1 more source

Feed Modification for Improved Energy and Protein Provision for Infants and Young Children in the Pediatric Critical Care Setting: A Scoping Review. [PDF]

Nutr Rev
Winderlich J, Little BS, Bendall C, Anderson A, Oberender F, Udy AA, Ridley EJ.   +6 more
europepmc   +1 more source

Media and information literacy among mothers in the 21st century: A scoping review protocol. [PDF]

PLoS One
Jiang Y, Mustaffa N, Aziz J, Cai X.
europepmc   +1 more source

Safe endoscopic colorectal stenting using a biliary balloon catheter: Balloon anchoring method. [PDF]

Endosc Int Open
Gomi K, Takano Y, Endo T, Matsubara D, Yoshida E, Tohata M, Nagahama M.   +6 more
europepmc   +1 more source