Results 71 to 80 of about 35,471,630 (314)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

Generation Mixing of Sneutrinos in Heavier Chargino Decay

open access: yes, 2005
The heavier chargino decay could yield two charged leptons of different generations, owing to generation mixing of sneutrinos. We discuss the possibility of producing $e$ and $\mu$ through this process in near future collider experiments.
For a recent review   +3 more
core   +1 more source

Graph Neural Networks: A Review of Methods and Applications [PDF]

open access: yesAI Open, 2018
Jie Zhou   +5 more
semanticscholar   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

A Review Reviewed [PDF]

open access: yesNature, 1894
I AM rather astonished at the criticism of my use of the term mineraliser in my book on the “Economic Geology of the United States,” made by a reviewer in a recent number of NATURE. Surely the sanction of the Century, Webster, and Worcester dictionaries, besides several scientific works, should be considered as warranting my use of the term, unless ...
openaire   +1 more source

Home - About - Disclaimer - Privacy